IADR Abstract Archives
Volumetric and Histologic Changes after Alveolar Ridge Preservation with L-PRF.
Objectives: To evaluate the effect of leucocyte and platelet-rich fibrin (L-PRF) with respect to the volumetric and histological changes of the tissues after its use for alveolar preservation.
Methods: Twelve patients in need of tooth extraction and single implant in the anterior area were included. After extraction, patients were randomized into two groups. Patients in the experimental group received alveolar preservation with (L-PRF) according to the recommendations described by Choukroun et al. in 2001, meanwhile the control group received no treatment (blood clot). Digital impressions were taken immediately after extraction, at seven days, at one month and four months in order to assess the volumetric changes in the profile and contour of the ridge.
Changes in the underlying hard tissues were evaluated by comparing the CBCT performed immediately after the extraction and the one performed at four months. At this time, the implant was placed using a surgical stent as guide for a trephin bur, with which a bone biopsy was taken for analysis by optical microscopy in order to assess trabecular width, amount of mineralized matrix and cell density. Patient related outcomes were registered at each visit. For the statistical analysis, intra and inter-group comparisons were performed with ANOVA test and Bonferroni's corrections. Qualitative variables were analyzed with frequency distributions and chi square. The level of significance was established at p<0.05.
Results: At 4 months, the horizontal tissue contours decreased concomitantly with an horizontal bone loss without significant differences at 2, 4 and 6mm from the bone crest, on the contrary, the soft tissue thickness increased in both groups. PROMs reported low level of postoperative pain and inflammation in favor of the test group at 7 days. Biopsies showed mature and well-structured mineralized bone in both groups.
Conclusions: Despite the limitations of the study it can be considered that the use of (L-PRF) can be an alternative for alveolar preservation therapies in sites udergoing dental extraction in the anterior sector, when the volumetric changes can become a challenge both for the aesthetic point of view and for the stability of the tissues.
Methods: Twelve patients in need of tooth extraction and single implant in the anterior area were included. After extraction, patients were randomized into two groups. Patients in the experimental group received alveolar preservation with (L-PRF) according to the recommendations described by Choukroun et al. in 2001, meanwhile the control group received no treatment (blood clot). Digital impressions were taken immediately after extraction, at seven days, at one month and four months in order to assess the volumetric changes in the profile and contour of the ridge.
Changes in the underlying hard tissues were evaluated by comparing the CBCT performed immediately after the extraction and the one performed at four months. At this time, the implant was placed using a surgical stent as guide for a trephin bur, with which a bone biopsy was taken for analysis by optical microscopy in order to assess trabecular width, amount of mineralized matrix and cell density. Patient related outcomes were registered at each visit. For the statistical analysis, intra and inter-group comparisons were performed with ANOVA test and Bonferroni's corrections. Qualitative variables were analyzed with frequency distributions and chi square. The level of significance was established at p<0.05.
Results: At 4 months, the horizontal tissue contours decreased concomitantly with an horizontal bone loss without significant differences at 2, 4 and 6mm from the bone crest, on the contrary, the soft tissue thickness increased in both groups. PROMs reported low level of postoperative pain and inflammation in favor of the test group at 7 days. Biopsies showed mature and well-structured mineralized bone in both groups.
Conclusions: Despite the limitations of the study it can be considered that the use of (L-PRF) can be an alternative for alveolar preservation therapies in sites udergoing dental extraction in the anterior sector, when the volumetric changes can become a challenge both for the aesthetic point of view and for the stability of the tissues.