IADR Abstract Archives
Regeneration with Enamel Matrix Derivative: Single Vs. Double Flap Approach
Objectives: The aim of this randomized controlled clinical trial was to compare the clinical, radiographic and patient-centered outcomes of two minimally invasive surgical techniques for periodontal regeneration of infrabony defects using enamel matrix derivative (EMD): single flap approach (SFA) and double flap approach (DFA).
Methods: A sample of 26 three-wall infrabony defects in 26 patients were randomly assigned to either SFA or DFA group, with the use of EMD in both groups. The main clinical parameters PPD, CAL, REC and BOP at 6 sites per tooth, mobility, as well as the radiographic parameters CEJ-base of the defect, CEJ-bone crest and the defect angle, were assessed and registered at baseline, 6 months and 12 months postoperative. Patient-centered outcomes such as pain, bleeding, swelling and hypersensitivity were also recorded using a Visual Analog Scale.
Descriptive statistical analysis included mean values and standard deviations (SD) of quantitative variables, while qualitative variables were expressed with frequencies and valid percentages. The tests used were Wilcoxon (quantitative variables), Fisher for the relationship of the qualitative variables and Mann-Whitney U test was used to analyze differences between groups.
Results: Both treatment groups resulted in an improvement in clinical and radiographic parameters at 12 months follow-up. Changes between baseline and 12 months were statistically significant for CAL and CEJ-bone crest in the SFA group only. When comparing differences between both groups at 12 months, no statistically significant differences were found in any clinical parameter (P>0.05). Both techniques resulted in low levels of pain, bleeding, hypersensitivity and swelling with no differences between treatment groups.
Conclusions: These data indicate that a SFA with EMD can be successfully applied to achieve a significant CAL gain and radiographic CEJ-bone crest change from baseline to 12 months follow-up.
Methods: A sample of 26 three-wall infrabony defects in 26 patients were randomly assigned to either SFA or DFA group, with the use of EMD in both groups. The main clinical parameters PPD, CAL, REC and BOP at 6 sites per tooth, mobility, as well as the radiographic parameters CEJ-base of the defect, CEJ-bone crest and the defect angle, were assessed and registered at baseline, 6 months and 12 months postoperative. Patient-centered outcomes such as pain, bleeding, swelling and hypersensitivity were also recorded using a Visual Analog Scale.
Descriptive statistical analysis included mean values and standard deviations (SD) of quantitative variables, while qualitative variables were expressed with frequencies and valid percentages. The tests used were Wilcoxon (quantitative variables), Fisher for the relationship of the qualitative variables and Mann-Whitney U test was used to analyze differences between groups.
Results: Both treatment groups resulted in an improvement in clinical and radiographic parameters at 12 months follow-up. Changes between baseline and 12 months were statistically significant for CAL and CEJ-bone crest in the SFA group only. When comparing differences between both groups at 12 months, no statistically significant differences were found in any clinical parameter (P>0.05). Both techniques resulted in low levels of pain, bleeding, hypersensitivity and swelling with no differences between treatment groups.
Conclusions: These data indicate that a SFA with EMD can be successfully applied to achieve a significant CAL gain and radiographic CEJ-bone crest change from baseline to 12 months follow-up.