IADR Abstract Archives
Efficacy of Hyaluronic Acid Dermal Fillers for Lip Augmentation: Meta-analysis
Objectives: Hyaluronic acid (HA) is widely used as a dermal filler for lip augmentation. However, its real beneficial effects are not well established. Therefore, our aim was to evaluate the efficacy of HA for lip augmentation and to assess the prevalence of rare adverse effects (AE) after HA injections.
Methods: We conducted our meta-analysis according to the PRISMA protocol. We performed the systematic literature search in Cochrane, Embase, and Pubmed. Studies were considered eligible if they were randomized controlled trials (RCTs), case series and case reports written in English. For HA efficacy evaluation, published data of responder rate were extracted and analyzed form each eligible study. Bias in studies, were assessed using The Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale. From the extracted data the untransformed proportion (random-effects DerSimonian-Laird method) for responder rate was calculated. For treatment related AEs descriptive statistics were used. For data analysis we used STATA software.
Results: The systematic literature search revealed 153 records after duplicate removal, 21 records were included for descriptive statistics and 12 records in the quantitative synthesis. The results indicate that the overall estimate of responders is 92% (ES=0.92, 95% CI: 0.80-0.99), (I2=88.46%, P<0.00) for the upper lips and 90% (ES=0.90, 95% CI: 0.82-0.96), (I2=74.02%, P<0.01) for the lower lips at 12 weeks after injection. The most frequent treatment related AE were swelling (39.8%), bruising (19.28%), erythema (6.33%) and herpes labialis (0.82%) among 1706 observants. Rare AEs (less than 0.2%) were lip exfoliation, aggregate of material, tumor like nodule, granulomatous foreign body reaction, oral dysaesthesia and angioedema).
Conclusions: Our meta-analysis reveals that lip augmentation with injectable HA is efficient and safe method for increasing lip fullness up to 12 weeks after augmentation. However, further RCTs are needed to strengthen the evidence on the efficacy of HA fillers. Supported by EFOP-3.6.2.-16-2017-0006.
Methods: We conducted our meta-analysis according to the PRISMA protocol. We performed the systematic literature search in Cochrane, Embase, and Pubmed. Studies were considered eligible if they were randomized controlled trials (RCTs), case series and case reports written in English. For HA efficacy evaluation, published data of responder rate were extracted and analyzed form each eligible study. Bias in studies, were assessed using The Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale. From the extracted data the untransformed proportion (random-effects DerSimonian-Laird method) for responder rate was calculated. For treatment related AEs descriptive statistics were used. For data analysis we used STATA software.
Results: The systematic literature search revealed 153 records after duplicate removal, 21 records were included for descriptive statistics and 12 records in the quantitative synthesis. The results indicate that the overall estimate of responders is 92% (ES=0.92, 95% CI: 0.80-0.99), (I2=88.46%, P<0.00) for the upper lips and 90% (ES=0.90, 95% CI: 0.82-0.96), (I2=74.02%, P<0.01) for the lower lips at 12 weeks after injection. The most frequent treatment related AE were swelling (39.8%), bruising (19.28%), erythema (6.33%) and herpes labialis (0.82%) among 1706 observants. Rare AEs (less than 0.2%) were lip exfoliation, aggregate of material, tumor like nodule, granulomatous foreign body reaction, oral dysaesthesia and angioedema).
Conclusions: Our meta-analysis reveals that lip augmentation with injectable HA is efficient and safe method for increasing lip fullness up to 12 weeks after augmentation. However, further RCTs are needed to strengthen the evidence on the efficacy of HA fillers. Supported by EFOP-3.6.2.-16-2017-0006.