IADR Abstract Archives
Resistin: A Potential Biomarker for Periodontitis
Objectives: Resistin is a fat-tissue derived adipocytokine and is associated with inflammatory response. The aim of this study was to evaluate saliva resistin levels as potential biomarker of periodontitis in individuals with or without type 2 diabetes mellitus (T2DM).
Methods: Thirty-two systemically and periodontally healthy individuals (H), 35 periodontitis (P) and 62 P+T2DM patients were enrolled in this study. Plaque index (PI), gingival index, bleeding on probing (BOP) %, probing depth (PD), and clinical attachment level (CAL) were recorded for all teeth. Unstimulated saliva samples were collected and concentrations of resistin were analyzed by using Luminex®-xMAP™ technique.
Results: Resistin levels were significantly lower in H group compared to P and P+T2DM groups (p=0.001). No significant differences in resistin levels were observed between P groups with and without T2DM (p=0.87). The PI, GI, BOP, and CAL levels were higher (p<0.05) in periodontitis patients with T2DM than in systemically healthy individuals.
Conclusions: A T2DM-independent relation between saliva resistin levels and periodontitis indicates a potential use of this adipocytokine in detection of periodontitis.
Methods: Thirty-two systemically and periodontally healthy individuals (H), 35 periodontitis (P) and 62 P+T2DM patients were enrolled in this study. Plaque index (PI), gingival index, bleeding on probing (BOP) %, probing depth (PD), and clinical attachment level (CAL) were recorded for all teeth. Unstimulated saliva samples were collected and concentrations of resistin were analyzed by using Luminex®-xMAP™ technique.
Results: Resistin levels were significantly lower in H group compared to P and P+T2DM groups (p=0.001). No significant differences in resistin levels were observed between P groups with and without T2DM (p=0.87). The PI, GI, BOP, and CAL levels were higher (p<0.05) in periodontitis patients with T2DM than in systemically healthy individuals.
Conclusions: A T2DM-independent relation between saliva resistin levels and periodontitis indicates a potential use of this adipocytokine in detection of periodontitis.