IADR Abstract Archives
A New Erythritol Containing Biocompatible Fluoride Toothpaste
Objectives: Basic functions of dentifrice and toothbrush are removal of the biofilm in order to prevent caries and gingivitis. An ideal toothpaste should provide maximal fluoride availability, optimal abrasivity, and ingredients that do not interfere with fluoride release but should have additional beneficial effects. Further, the effect of dentifrices and their ingredients on cells of the oral cavity is of importance.
Methods: We investigated several chemical, physical and biological parameters of a new toothpaste (AirFlow) that contains besides fluoride also erythritol but no SLS and compared them to commercially available toothpastes (Zendium-Ze, Sensodyne-Se, OdolMed-OM, OralB-OB). Wettability and abrasion on enamel, pH, free fluoride, the half lethal concentration (LC50) as well as the proliferation behaviour on gingival (GF), periodontal ligament (PDL) and mouse fibroblasts (L929) were tested.
Results: AirFlow-AF had the largest contact angle on enamel (38.4°), OB the lowest (18.4°) The abrasion on enamel after 18000 strokes was 0.02 µm (AF), 0.08 µm (Ze), 0.1 µm (Se), 0.16 µm (OM), 0.59 µm (OB). The pH of the slurries was between 5.6 (OB) and 7.7 (AF); free fluoride ranged between 1025 ppm (OB) and 1400 ppm (AF). The mean LC50 values of AirFlow on GF, PDL, and L929 were 16.2, 10.9, and 11.1, respectively. In comparison, the four commercially available toothpastes showed mean LC50 values of 1.5 (OB), 1.2 (OM), 1.4 (Se), and 27.7 (Ze) on GF. Mean LC50 values on PDL and L929 were 1.0 and 0.4 (OB), 3.7 and 0.9 (OM), 1.2 and 1.2 (Se), as well as 25.4 and 5.6 (Ze), respectively. Proliferation behaviour mainly confirmed the LC 50 values. While cells after stimulation with AF returned to almost unimpaired proliferation behaviour at 6%, cells are still strongly impaired after stimulation with all tested commercially toothpastes.
Conclusions: The new toothpaste (AF) showed low abrasivity, large contact angles, high availability of free fluoride and high biocompatibility to different cell lines.
Methods: We investigated several chemical, physical and biological parameters of a new toothpaste (AirFlow) that contains besides fluoride also erythritol but no SLS and compared them to commercially available toothpastes (Zendium-Ze, Sensodyne-Se, OdolMed-OM, OralB-OB). Wettability and abrasion on enamel, pH, free fluoride, the half lethal concentration (LC50) as well as the proliferation behaviour on gingival (GF), periodontal ligament (PDL) and mouse fibroblasts (L929) were tested.
Results: AirFlow-AF had the largest contact angle on enamel (38.4°), OB the lowest (18.4°) The abrasion on enamel after 18000 strokes was 0.02 µm (AF), 0.08 µm (Ze), 0.1 µm (Se), 0.16 µm (OM), 0.59 µm (OB). The pH of the slurries was between 5.6 (OB) and 7.7 (AF); free fluoride ranged between 1025 ppm (OB) and 1400 ppm (AF). The mean LC50 values of AirFlow on GF, PDL, and L929 were 16.2, 10.9, and 11.1, respectively. In comparison, the four commercially available toothpastes showed mean LC50 values of 1.5 (OB), 1.2 (OM), 1.4 (Se), and 27.7 (Ze) on GF. Mean LC50 values on PDL and L929 were 1.0 and 0.4 (OB), 3.7 and 0.9 (OM), 1.2 and 1.2 (Se), as well as 25.4 and 5.6 (Ze), respectively. Proliferation behaviour mainly confirmed the LC 50 values. While cells after stimulation with AF returned to almost unimpaired proliferation behaviour at 6%, cells are still strongly impaired after stimulation with all tested commercially toothpastes.
Conclusions: The new toothpaste (AF) showed low abrasivity, large contact angles, high availability of free fluoride and high biocompatibility to different cell lines.