Platelet Rich in Grown Factors in Control of Pain, Postextraction Dental.

Objectives: To assess the effect on pain of Platelet Rich in Grown Factors (PRGF, Endoret®) in patients undergoing tooth extraction
Methods: Twenty patients (n=20), 8 men and 12 women, age range between 32 and 59 years, were selected as candidates to extract a superior canine, right or left, due to cariogenic problems. Inclusion criteria: patients of legal age, indication of simple exodontia and possibility of observation during a set time (15 days). Exclusion criteria: Teeth that were not canine, severe periodontal infection or disease, uncontrolled systemic disease and have received, in the 30 days prior to the intervention, treatment with corticosteroids/anti-inflammatories. All patients received antibiotic prophylaxis 48 hours before the intervention. All the extractions were made by the same operator. The patients were divided into two groups: Group 1, patients with socket treated by PRGF Endoret® and Group 2 (control), whose socket healed by secondary intention. The main variable studied was pain (quantitative variable), by VAS at 24 h, 72 h, 7 days and 15 days. PRGF is prepared by centrifuging the patient's blood, in 5 ml tubes, with citrate as anticoagulant (PRGF SistemVR®, BTI Biotechnology Institute, 1800 rev / min).One-way ANOVA was used for data processing. All patients were given informed consent, according to Helsinki declaration. The study was submitted to the Center's Bioethics Committee
Results: After 24 h the group treated with PRGF showed a percentage of pain of 3.9% vs. to 5.9% in the control group. At 72 h, 1.5%, the group treated with PRGF Endoret® vs. 3.9% of the control group. At 7-15 days, the pain had disappeared in both groups. One-way ANOVA (Newman Keuls) was significant at 24 h and 72 h p<0.0006
Conclusions: The group treated with PRGF showed percentages of pain significantly lower than the control group