IADR Abstract Archives
Novel Varnishes Formulated for Prevention and/or Treatment of White Spot Lesions
Objectives: To develop light-cured strontium fluoride containing bioactive glass varnishes by integrating a BAG with a resin producing a material with remineralisation potential to prevent and/or treat white spot lesions. To confirm the ability of the material to release ions over a sustained period of immersion in three different solutions and to correlate ion release and BAG loading.
Methods: Experimental BAG powders were prepared utilising the melt quench route then integrated with a resin to form a light-cured mixture. Specimens (10mm * 0.35mm) were prepared in three different groups according to the following BAG to resin ratios: 20:80, 40:60, and 60:40. Two specimens were immersed in one of three different 10ml solutions (Artificial saliva, pH = 4; artificial saliva, pH = 7; and Tris buffer solution, pH =7.3) over seven time periods from 0 hours to 3 months. The resulting solution was evaluated using ISE, ICP and pH tests to determine the ion release and pH values, respectively. The discs were then investigated using FTIR, XRD and SEM.
Results: A significant increase in fluoride ion release was detected after 3 hours for all samples immersed in all solutions and increases with time. There is a linear correlation between ion release and BAG loading. The pH value was significantly increased after 3 hours of sample immersion and reaches a constant level over the immersion period. Apatite formation was confirmed by using FTIR, XRD and SEM with its formation increasing with time.
Conclusions: The BAG varnishes have the ability to release remineralising ions especially in acidic environments and have the ability to form apatite. These BAG varnishes have potential to prevent and/or treat white spot lesions via the release of fluoride, phosphate, calcium and strontium. However, further laboratory and clinical investigation are required to prove the potential benefit of these varnishes.
Methods: Experimental BAG powders were prepared utilising the melt quench route then integrated with a resin to form a light-cured mixture. Specimens (10mm * 0.35mm) were prepared in three different groups according to the following BAG to resin ratios: 20:80, 40:60, and 60:40. Two specimens were immersed in one of three different 10ml solutions (Artificial saliva, pH = 4; artificial saliva, pH = 7; and Tris buffer solution, pH =7.3) over seven time periods from 0 hours to 3 months. The resulting solution was evaluated using ISE, ICP and pH tests to determine the ion release and pH values, respectively. The discs were then investigated using FTIR, XRD and SEM.
Results: A significant increase in fluoride ion release was detected after 3 hours for all samples immersed in all solutions and increases with time. There is a linear correlation between ion release and BAG loading. The pH value was significantly increased after 3 hours of sample immersion and reaches a constant level over the immersion period. Apatite formation was confirmed by using FTIR, XRD and SEM with its formation increasing with time.
Conclusions: The BAG varnishes have the ability to release remineralising ions especially in acidic environments and have the ability to form apatite. These BAG varnishes have potential to prevent and/or treat white spot lesions via the release of fluoride, phosphate, calcium and strontium. However, further laboratory and clinical investigation are required to prove the potential benefit of these varnishes.