IADR Abstract Archives
Perioperative amoxicillin preventing dental implant failures and postoperative infections. Meta-analysis
Objectives: Assess the effect of Amoxicillin to reduce the incidence of dental implant failures and postoperative infections following dental implant placement.
Methods: Design: Systematic review and meta-analysis. Recommendations proposed by PRISMA were followed. Data sources: Pubmed, Cochrane, Science Direct, and EMBASE via OVID were searched up to November 2016 and (Amoxicillin OR antibiotics) AND (dental implant failure OR postoperative infection) AND (dental implant placement OR dental implant surgery) were used as key words. References of each article were reviewed. Meeting abstracts published were searched. Only randomized controlled clinical trials using amoxicillin were included. There were no restrictions regarding language. Outcome measures were set on incidence of dental implant failures and postoperative infections after dental implant surgery without any restriction on their definition. Three reviewers undertook independently risk of bias assessment and data extraction. A meta-analysis of binary data using fixed-effects models was performed with Stata statistical software version 12.0. Risk ratios (RR) and 95% confidence intervals (CI) were estimated. Forest, l`Abbe and Funnel plots were constructed. Any adverse effect related to Amoxicillin was reported.
Results: Out of 15 studies, 9 eligible trials with 2982 surgeries were considered, 1513 in the experimental group and 1469 in the control group. Overall RR=0.53 (95% CI, of 0.34 to 0.82) for the implant-failures analysis (P=0.005) and RR=0.76 (95% CI, of 0.47 to 1.22) for postoperative-infections analysis (P=0.250). There is no evidence of heterogeneity: I2=0.0%, chi-squared test p=0.998. Amoxicillin did not cause a larger proportion of adverse reactions than placebo.
Conclusions: The use of Amoxicillin is effective and efficacious in the prevention of implant failures, but not significantly for preventing postoperative infections following dental implant placement. It would be necessary to treat between 33 and 167 patients (95% CI of the overall NNT) with Amoxicillin to prevent one case of implant failure.
Methods: Design: Systematic review and meta-analysis. Recommendations proposed by PRISMA were followed. Data sources: Pubmed, Cochrane, Science Direct, and EMBASE via OVID were searched up to November 2016 and (Amoxicillin OR antibiotics) AND (dental implant failure OR postoperative infection) AND (dental implant placement OR dental implant surgery) were used as key words. References of each article were reviewed. Meeting abstracts published were searched. Only randomized controlled clinical trials using amoxicillin were included. There were no restrictions regarding language. Outcome measures were set on incidence of dental implant failures and postoperative infections after dental implant surgery without any restriction on their definition. Three reviewers undertook independently risk of bias assessment and data extraction. A meta-analysis of binary data using fixed-effects models was performed with Stata statistical software version 12.0. Risk ratios (RR) and 95% confidence intervals (CI) were estimated. Forest, l`Abbe and Funnel plots were constructed. Any adverse effect related to Amoxicillin was reported.
Results: Out of 15 studies, 9 eligible trials with 2982 surgeries were considered, 1513 in the experimental group and 1469 in the control group. Overall RR=0.53 (95% CI, of 0.34 to 0.82) for the implant-failures analysis (P=0.005) and RR=0.76 (95% CI, of 0.47 to 1.22) for postoperative-infections analysis (P=0.250). There is no evidence of heterogeneity: I2=0.0%, chi-squared test p=0.998. Amoxicillin did not cause a larger proportion of adverse reactions than placebo.
Conclusions: The use of Amoxicillin is effective and efficacious in the prevention of implant failures, but not significantly for preventing postoperative infections following dental implant placement. It would be necessary to treat between 33 and 167 patients (95% CI of the overall NNT) with Amoxicillin to prevent one case of implant failure.