IADR Abstract Archives
Microbiological outcomes following non-surgical periodontal treatment and a 3 or 7 days systemic administration of Amoxicillin and Metronidazole
Objectives: To evaluate the microbiological changes after scaling and root planing (SRP) combined with systemic administration of amoxicillin (AMX) and metronidazole (MET) for 3- or 7-days.
Methods: 102 patients with chronic periodontitis (ChP) were randomly treated as follows: SRP (group A), SRP+AMX+MET (500mg 3 times-per-day for 3 days, group B) or with SRP+AMX+MET (500mg 3 times-per-day for 7 days, group C). At baseline, at 2 weeks, at 3 and 6 months after treatment, clinical parameters and microbiological profiles were evaluated. Pooled microbiological samples were taken from the deepest pocket in each quadrant and A. actinomicetemcomitans, P. gingivalis, T. forsythia, P. intermedia, T. denticola, P. micra, F. alocis and C. rectus were determined by real-time polymerase-chain-reaction
Results: 91 patients have completed the evaluation period of 6 months. At baseline, there were no significant differences in terms of mean counts of the evaluated periodontopathogens. At all follow-ups, significant reduction (p<0.05, Wilcoxon Test) of P. gingivalis, T. denticola and T. forsythia was registered in all treatment groups. A significant reduction of A. actinomycetemcomitans was registered only 2 weeks after treatment with the two antibiotic protocols. At 6 months, P. gingivalis was significantly more reduced (p<0.05) in groups B and C as compared to the placebo group, with no significant differences between the two antibiotic groups (p>0.05). These groups also presented a significant reduction in the number of patients positive for P. gingivalis, T. denticola, P. micra, F. nucleatum, C. rectus and F. alocis as compared to placebo at 6 months, without a significant difference between them. These microbiological findings were in line with the clinical outcomes
Conclusions: The present results have shown that: a) in patients with severe chronic periodontitis patients a 3- and 7-days systemic administration of AMX+MET adjunctive to SRP resulted in significant greater reductions of several periodontopathogens compared to SRP alone and b) the two antibiotic regimens yielded similar microbiological improvements.
Methods: 102 patients with chronic periodontitis (ChP) were randomly treated as follows: SRP (group A), SRP+AMX+MET (500mg 3 times-per-day for 3 days, group B) or with SRP+AMX+MET (500mg 3 times-per-day for 7 days, group C). At baseline, at 2 weeks, at 3 and 6 months after treatment, clinical parameters and microbiological profiles were evaluated. Pooled microbiological samples were taken from the deepest pocket in each quadrant and A. actinomicetemcomitans, P. gingivalis, T. forsythia, P. intermedia, T. denticola, P. micra, F. alocis and C. rectus were determined by real-time polymerase-chain-reaction
Results: 91 patients have completed the evaluation period of 6 months. At baseline, there were no significant differences in terms of mean counts of the evaluated periodontopathogens. At all follow-ups, significant reduction (p<0.05, Wilcoxon Test) of P. gingivalis, T. denticola and T. forsythia was registered in all treatment groups. A significant reduction of A. actinomycetemcomitans was registered only 2 weeks after treatment with the two antibiotic protocols. At 6 months, P. gingivalis was significantly more reduced (p<0.05) in groups B and C as compared to the placebo group, with no significant differences between the two antibiotic groups (p>0.05). These groups also presented a significant reduction in the number of patients positive for P. gingivalis, T. denticola, P. micra, F. nucleatum, C. rectus and F. alocis as compared to placebo at 6 months, without a significant difference between them. These microbiological findings were in line with the clinical outcomes
Conclusions: The present results have shown that: a) in patients with severe chronic periodontitis patients a 3- and 7-days systemic administration of AMX+MET adjunctive to SRP resulted in significant greater reductions of several periodontopathogens compared to SRP alone and b) the two antibiotic regimens yielded similar microbiological improvements.