IADR Abstract Archives
Evaluation of the Effects of the Probiotic Lozenges (Prodentis) or Subantimicrobial Dose Doxycycline (Periostat) as Adjuncts to Initial Periodontal Therapy: Double-blinded, Placebo Control, Clinical Trial
Objectives: The objective of this study was to evaluate the effects of lozenges containing L. reuteri or subantimicrobial dose doxycycline as an adjuvant treatment to initial periodontal therapy for chronic periodontitis patients both clinically and microbiologically.
Methods: A total of 30 patients were selected and randomly divided into 3 groups. Each patient had at least 2 teeth with one approximal site each with a probing depth (PD) of 5-7 mm and gingival index (GI) of ≥2 in each quadrant. Group I received scaling and root planing (SRP) plus L. reuteri-containing lozenges, Group II, received SRP+subantimicrobial dose doxycycline, Group III received SRP plus placebo. The plaque index (PI), GI, bleeding on probing (BoP), PD, and relative attachment level were measured. Microbiological sampling was performed at baseline and on day 90 were analysed by culturing.
Results: At the end of the observation period, the measured PI, GI, BoP, and PD as well as the total viable cell counts and the proportions of obligate anaerobes were significantly (p<0.05) lower in all treatment groups. Group I and Group II, revealed statistically significant (p<0.05) results compared to Group III in all investigated parameters.
Conclusions: Within the limits of this study, both of the adjunctive treatment modalities resulted in better clinical and microbiological outcomes. Further long-term studies are needed to evaluate the effects of these adjuncts in terms of immunological parameters.
Methods: A total of 30 patients were selected and randomly divided into 3 groups. Each patient had at least 2 teeth with one approximal site each with a probing depth (PD) of 5-7 mm and gingival index (GI) of ≥2 in each quadrant. Group I received scaling and root planing (SRP) plus L. reuteri-containing lozenges, Group II, received SRP+subantimicrobial dose doxycycline, Group III received SRP plus placebo. The plaque index (PI), GI, bleeding on probing (BoP), PD, and relative attachment level were measured. Microbiological sampling was performed at baseline and on day 90 were analysed by culturing.
Results: At the end of the observation period, the measured PI, GI, BoP, and PD as well as the total viable cell counts and the proportions of obligate anaerobes were significantly (p<0.05) lower in all treatment groups. Group I and Group II, revealed statistically significant (p<0.05) results compared to Group III in all investigated parameters.
Conclusions: Within the limits of this study, both of the adjunctive treatment modalities resulted in better clinical and microbiological outcomes. Further long-term studies are needed to evaluate the effects of these adjuncts in terms of immunological parameters.