Clinical and Radiographical Evaluation of Hyaluronic acid and Bovine Derived Xenograft Combination versus Bovine Derived Xenograft Alone in Intrabony Defects

Objectives: The purpose of this randomized, parallel and controlled clinical trial was to compare the clinical and radiographical effectiveness of a new biomaterial including hyaluronic acid (HA) and bovine derived xenograft (BDX) combination versus of a bovine derived xenograft (BDX) application in the treatment of periodontal intrabony defects.
Methods: Twenty advanced chronic periodontitis patients who had intrabony component of ≥3 mm and radioghraphical intrabony defects with an associated probing debth (PD) of ≥ 5mm were included. 54 intrabony defects were surgically treated with the HA + BDX (1st group) and 55 intrabony defects were treated with BDX alone (2nd group). Plaque and sulcus bleeding indices, PD, marginal recession, relative attachment and bone levels and radiographic bone level were recorded at baseline and 12 months after surgery.
Results: At 12 months, intragroup comparisons for all evaluated clinical and radiographical parameters revealed statistically significant differences compared to baseline (p<0.05). Considering the deepest site of the defects, group 1 and 2 showed a mean PD reduction of 3,38±1,29 mm and 2,99±0,75 mm, attachment gain of 2,56±1,26 mm and 2,33±0,57 mm, recession of 0,79±0,88 mm and 0,66±0,56 mm, clinical bone gain of 2,8±1,45 mm and 2,09±0,65 mm and radiographic bone gain of 2,38±1,34 mm and 1,83±0,95 mm, respectively. Intergroup comparisons for all parameters were found to be insignificant (p>0.05).
Conclusions: Within the limits of this study, it can be concluded that both HA+BDX and BDX treatments demonstrated similar clinical improvements in intrabony periodontal defects.