Tree-year clinical results for treatment of multiple gingival recession defects with Titanium Prepared Platelet Rich Fibrin: a case series.

Objectives: In our previous studies, we developed a platelet rich product called titanium prepared platelet-rich fibrin (T-PRF). T-PRF, is based on the hypothesis that titanium is more effective at activating platelets than the silica activators used with glass tubes in platelet-rich fibrin. We established that the fibrin carpet formed with titanium had a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed with glass. There has been no study to date evaluating the long-term predictability of T-PRF membrane for root coverage. This study evaluated the long-term effectiveness of a T-PRF membrane combined with a coronally repositioned flap surgery in a treatment of deep gingival recession defects.
Methods: Four subjects with 18 Miller Class I or II defects were selected. The defects were ≥ 3.0 mm deep and were treated with a coronally positioned flap associated with a T-PRF membrane. Probing depth (PD), clinical attachment level (CAL), gingival recession depth (GRD), and keratinized tissue width (KT) were assessed at baseline, 1 month, 6 months , 1 year, 2 years, and 3 years after the surgery.
Results: The mean initial gingival recessions were 4.81 mm. Three years after surgery mean root coverage was 95.4 %.
Conclusions: Within the limits of this study, the long-term results demonstrated that T-PRF membrane combined with a coronally repositioned flap procedure is safe and effective in a treatment of class I and II Miller gingival recessions without a requirement for additional surgery.