Titanium Prepared Platelet Rich Fibrin Combined with Enamel Matrix Derivative in the Treatment of Periodontal Intraosseous Defect: A Case Report

Objectives: We developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The fibrin carpet formed in T-PRF have a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed in platelet rich fibrin activated in glass tube. T-PRF, a rich source of autologous growth factors and cytokines, is becoming an important therapeutic approach in the management of periodontal osseous defects. Today in the clinical practices both in periodontal osseous and mucogingival surgeries the most widely used biological factor is the Enamel Matrix Derivative (EMD). The aim of this case report is to present the management of an intrabony osseous defect with T-PRF& EMD with clinical and radiographic evaluations.
Methods: A 45 year-old systemically healthy female patient is presented with an intrabony periodontal defect in relation to the mandibular first molar. Digital radiographic analysis revealed angular bone loss in the region. The defect had probing pocket depths (PPD) of 9 mm and loss of clinical attachment level (CAL) was treated by the use of T-PRF combined with EMD. Clinical and radiographic parameters were recorded at baseline and at 12 months post-operatively.
Results: Twelve months follow up revealed a significant reduction in PPD and CAL gain. At the end of 12 months as well as radiographic bone formation was observed.
Conclusions: The present results of this report suggest that treatment of deep intrabony periodontal defects by the use of T-PRF and EMD combination provides a rapid, effective and safe grafting modality.