IADR Abstract Archives
The Influence of Non-surgical Periodontal Treatment on Circulating Markers of Inflammation in Subjects with Type 2 Diabetes and Chronic Periodontitis: The Diabetes And Periodontal Therapy Trial
Objectives: Chronic periodontitis and type 2 diabetes are associated with increased risk for cardiovascular disease. Some evidence suggests that periodontal therapy may reduce circulating markers of inflammation. The purpose of this study was to test whether non-surgical periodontal treatment influenced circulating biomarkers associated with cardiovascular disease in persons with type 2 diabetes (DM) and moderate to advanced chronic periodontitis.
Methods: The Diabetes and Periodontal Therapy Trial (DPTT) was a 6-month, single-masked, randomized, multi-center clinical trial. The treatment group (n=257) received scaling and root planing, oral hygiene instruction, and chlorhexidine oral rinse at baseline and periodontal maintenance therapy at three and six months. The control group (n=257) received delayed treatment after the six month study period. Blood samples were collected at baseline, and six months and analyzed for a panel of pro- and anti-inflammatory biomarkers: HS-CRP, E-Selectin, TNF-alpha, VCAM, IL-6, IL-8, ICAM, and IL-10. Correlation between biomarkers, diabetes related variables, and periodontal disease measures were explored, and change from baseline of biomarkers were compared between treatment and control groups.
Results: Among all biomarkers at baseline, E-selectin, was significantly associated with HbA1c, BMI, fasting glucose, and fasting insulin while IL-6 was significantly correlated with HS-CRP, BMI, and E-selectin. No significant correlations between periodontal measures and biomarkers were noted at baseline or after therapy. Periodontal disease measures were significantly improved at six months, while diabetes outcomes and circulating biomarkers showed no significant change.
Conclusions: Non-surgical periodontal therapy did not result in significant changes to serum biomarker profiles in patients with type 2 diabetes and moderate to advanced chronic periodontitis.
Methods: The Diabetes and Periodontal Therapy Trial (DPTT) was a 6-month, single-masked, randomized, multi-center clinical trial. The treatment group (n=257) received scaling and root planing, oral hygiene instruction, and chlorhexidine oral rinse at baseline and periodontal maintenance therapy at three and six months. The control group (n=257) received delayed treatment after the six month study period. Blood samples were collected at baseline, and six months and analyzed for a panel of pro- and anti-inflammatory biomarkers: HS-CRP, E-Selectin, TNF-alpha, VCAM, IL-6, IL-8, ICAM, and IL-10. Correlation between biomarkers, diabetes related variables, and periodontal disease measures were explored, and change from baseline of biomarkers were compared between treatment and control groups.
Results: Among all biomarkers at baseline, E-selectin, was significantly associated with HbA1c, BMI, fasting glucose, and fasting insulin while IL-6 was significantly correlated with HS-CRP, BMI, and E-selectin. No significant correlations between periodontal measures and biomarkers were noted at baseline or after therapy. Periodontal disease measures were significantly improved at six months, while diabetes outcomes and circulating biomarkers showed no significant change.
Conclusions: Non-surgical periodontal therapy did not result in significant changes to serum biomarker profiles in patients with type 2 diabetes and moderate to advanced chronic periodontitis.