IADR Abstract Archives
Effectiveness of Chlorhexidine in the prophylaxis of alveolar osteitis. Meta-analysis
Objectives: To test the effect of Chlorhexidine on reducing the incidence of alveolar osteitis following tooth extraction
Methods: Design: Systematic review and meta-analysis. Data sources: Pubmed, Cochrane, Science Direct, and ISI-Web-of-knoledge. Searched up to 17 January 2015 (chlorhexidine) AND (alveolar osteitis OR dry socket) AND (exodontia OR extraction OR removal) were used as key words for title and abstract. References of each article were also reviewed. Meeting Abstracts published were searched. We only included randomized controlled clinical trials using chlorhexidine. There were no restrictions regarding language or date of publication. The outcome measure was set on incidence of alveolar osteitis after tooth extraction. There was no restriction on the definition of alveolar osteitis. Any specific adverse effects related to chlorhexidine were reported. Three review authors independently undertook risk of bias assessment and data extraction. We followed the recommendations proposed by PRISMA. We used the statistical program Stata version 12.0. The statistical technique was meta-analysis of binary data using fixed-effects models. We estimated risk ratios (RR) and 95% confidence intervals (CI). We made Forest, Labbe and Funnel plots
Results: Out of 25 studies, eighteen eligible trials with 2824 extractions were considered, 1458 in the experimental group and 1366 in the control group. The chlorhexidine treatment is effective in the prevention of dry socket. The overall risk ratio (RR) is 0.66 with a 95% confidence interval (CI) of 0.59 to 0.77. The RR was statistically significant p<0.001. There is no evidence of heterogeneity: I2=24%, chi-squared test p=0.147. Chlorhexidine did not cause higher adverse reactions than placebo
Conclusions: There is evidence to support the use of chlorhexidine to reduce the incidence of alveolar osteitis following tooth extractions. It would be necessary to treat with chlorhexidine between four and seven patients (95% CI of the overall NNT) to prevent one case of dry socket
Methods: Design: Systematic review and meta-analysis. Data sources: Pubmed, Cochrane, Science Direct, and ISI-Web-of-knoledge. Searched up to 17 January 2015 (chlorhexidine) AND (alveolar osteitis OR dry socket) AND (exodontia OR extraction OR removal) were used as key words for title and abstract. References of each article were also reviewed. Meeting Abstracts published were searched. We only included randomized controlled clinical trials using chlorhexidine. There were no restrictions regarding language or date of publication. The outcome measure was set on incidence of alveolar osteitis after tooth extraction. There was no restriction on the definition of alveolar osteitis. Any specific adverse effects related to chlorhexidine were reported. Three review authors independently undertook risk of bias assessment and data extraction. We followed the recommendations proposed by PRISMA. We used the statistical program Stata version 12.0. The statistical technique was meta-analysis of binary data using fixed-effects models. We estimated risk ratios (RR) and 95% confidence intervals (CI). We made Forest, Labbe and Funnel plots
Results: Out of 25 studies, eighteen eligible trials with 2824 extractions were considered, 1458 in the experimental group and 1366 in the control group. The chlorhexidine treatment is effective in the prevention of dry socket. The overall risk ratio (RR) is 0.66 with a 95% confidence interval (CI) of 0.59 to 0.77. The RR was statistically significant p<0.001. There is no evidence of heterogeneity: I2=24%, chi-squared test p=0.147. Chlorhexidine did not cause higher adverse reactions than placebo
Conclusions: There is evidence to support the use of chlorhexidine to reduce the incidence of alveolar osteitis following tooth extractions. It would be necessary to treat with chlorhexidine between four and seven patients (95% CI of the overall NNT) to prevent one case of dry socket