IADR Abstract Archives
Effectiveness of systematic periodontal treatment in HIV-infected patients with chronic periodontitis after 11 years
Objectives: Highly active antiretroviral therapy (HAART) significantly changed the incidence and prevalence of periodontal diseases in HIV-infected patients focusing chronic periodontitis today; but only little evidence is available about its long-term treatment outcomes.
It was therefore the purpose of study to investigate clinical treatment outcomes of systematic periodontal treatment including supportive periodontal care after for 11 years in HIV-infected patients with chronic periodontitis as compared to non HIV-infected patients.
Methods: This was a longitudinal prospective, open-label, parallel-group cohort study conducted in Germany in 24 subjects. Systematic periodontal treatment was defined as non-surgical active periodontal treatment by scaling and root planing and subsequent supportive periodontal care at regularly intervals.
To measure the effectiveness, reductions of periodontal pocket probing depths were chosen as the primary study end point. Secondary study end points were the plaque index, the gingival index, and the semiquantitative subgingival biofilm composition of 20 periodontal pathogens. Tooth loss was defined as safety end point. Statistical analysis comprised signed tests (intra-group comparison), Wilcoxon tests (inter-group comparison), and McNemar tests (binary data) at 0.05 significance level.
Results: Periodontal pocket probing depths reductions in HIV-infected subjects (-0.4 mm) demonstrated no statistically significant differences as compared to non HIV-infected patients (-0.3 mm) (p = 0.5). The extent of the oral biofilm and the extent of gingivitis in the test group was significantly lower as compared to controls (p <0.002). The subgingival biofilm composition demonstrated differences between the groups in terms of amplitude and some periodontal species (B. forsythia, S. gordinii). No tooth loss was documented in the test group, whereas mean 0.2 teeth were lost in controls (p = 0.7).
Conclusions: Within the limits of this study, it is concluded that systematic periodontal treatment including supportive periodontal care is an effective treatment concept in virologically controlled HIV infection.
It was therefore the purpose of study to investigate clinical treatment outcomes of systematic periodontal treatment including supportive periodontal care after for 11 years in HIV-infected patients with chronic periodontitis as compared to non HIV-infected patients.
Methods: This was a longitudinal prospective, open-label, parallel-group cohort study conducted in Germany in 24 subjects. Systematic periodontal treatment was defined as non-surgical active periodontal treatment by scaling and root planing and subsequent supportive periodontal care at regularly intervals.
To measure the effectiveness, reductions of periodontal pocket probing depths were chosen as the primary study end point. Secondary study end points were the plaque index, the gingival index, and the semiquantitative subgingival biofilm composition of 20 periodontal pathogens. Tooth loss was defined as safety end point. Statistical analysis comprised signed tests (intra-group comparison), Wilcoxon tests (inter-group comparison), and McNemar tests (binary data) at 0.05 significance level.
Results: Periodontal pocket probing depths reductions in HIV-infected subjects (-0.4 mm) demonstrated no statistically significant differences as compared to non HIV-infected patients (-0.3 mm) (p = 0.5). The extent of the oral biofilm and the extent of gingivitis in the test group was significantly lower as compared to controls (p <0.002). The subgingival biofilm composition demonstrated differences between the groups in terms of amplitude and some periodontal species (B. forsythia, S. gordinii). No tooth loss was documented in the test group, whereas mean 0.2 teeth were lost in controls (p = 0.7).
Conclusions: Within the limits of this study, it is concluded that systematic periodontal treatment including supportive periodontal care is an effective treatment concept in virologically controlled HIV infection.