IADR Abstract Archives
Anodized vs. Sandblasted Implant Surfaces in Grafted-Dehiscence Defect Animal Model
Objectives: The effect of impact of surface characteristics on osseointegration and bone apposition were investigated by comparing a novel gradient anodised (NGA) functionalized, commercially available, implant (NobelActive, TiUltra NP, commercially pure Titanium, 3.5 × 8.5 mm, Nobel Biocare AG, Switzerland) with custom-made replicas of the NGA implant geometry, modified with the SLActive and SLA surface (Replica of NobelActive, SLActive or SLA, Roxolid, 3.5 x 8.5 mm, Institut Straumann AG, Switzerland).
Methods: Crestal bone formation was analyzed histologically and histomorphometrically using a standardized 3mm acute type buccal dehiscence model grafted with deproteinized bovine bone mineral (DBBM-Bio-Oss™,Geistlich®) and covered with a porcine collagen membrane (Bio-Gide™,Geistlich®) after 2 weeks(2W,n=6) and 8weeks(8W,n=8) of healing. Each animal received one NGA, SLActive and SLA implant. The primary outcome was bone-to-implant contact in the dehiscence defect(dBIC). Secondary outcomes included: first-bone-to-implant-contact(fBIC), new-bone-height(NBH), vertical-bone-creep(VBC) and bone-area-to-total-area(BATA). A multivariate linear regression model, with the factor “animal” modelled as a random effect, was adjusted for multiple comparison using Dunnett-Hsu method with a significance level of α<0.05.
Results: At 2W dBIC was higher for SLActive(µ=17.1,S.D=7.5,p<0.05) compared to NGA(µ=2.5,S.D=5.5) and 8W both SLActive(µ=47.8,S.D=18.5,p<0.001) and SLA(µ=35.1,S.D19.0,p<0.01) demonstrated higher dBIC than NGA(µ=3.2,S.D3.9). At 2W fBIC significant closer to the crest for SLActive(µ=-14072,S.D=419.5,p<0.01) and SLA(µ=-1971.5,S.D=590.6,p<0.05) compared to NGA(µ=-2567.1,S.D=416.8). At 8 weeks both SLActive(µ=-461.3,S.D=643.4,p<0.01) and SLA(µ=-652.1,S.D=581.8,p<0.01) fBIC was significantly closer to the crest than NGA(µ=-1633.5,S.D=763.6). At 2W and 8W there was no evidence of a difference(p>0.05) in NBH or BATA between the groups.
Conclusions: At 2 and 8 weeks the SLActive surface compared to NGA demonstrated significantly higher levels of dBIC, fBIC and VBC. SLA surface demonstrated significantly higher levels of fBIC and VBC at 2 weeks and dBIC, fBIC and VBC at 8 weeks compared to the NGA surface.
Methods: Crestal bone formation was analyzed histologically and histomorphometrically using a standardized 3mm acute type buccal dehiscence model grafted with deproteinized bovine bone mineral (DBBM-Bio-Oss™,Geistlich®) and covered with a porcine collagen membrane (Bio-Gide™,Geistlich®) after 2 weeks(2W,n=6) and 8weeks(8W,n=8) of healing. Each animal received one NGA, SLActive and SLA implant. The primary outcome was bone-to-implant contact in the dehiscence defect(dBIC). Secondary outcomes included: first-bone-to-implant-contact(fBIC), new-bone-height(NBH), vertical-bone-creep(VBC) and bone-area-to-total-area(BATA). A multivariate linear regression model, with the factor “animal” modelled as a random effect, was adjusted for multiple comparison using Dunnett-Hsu method with a significance level of α<0.05.
Results: At 2W dBIC was higher for SLActive(µ=17.1,S.D=7.5,p<0.05) compared to NGA(µ=2.5,S.D=5.5) and 8W both SLActive(µ=47.8,S.D=18.5,p<0.001) and SLA(µ=35.1,S.D19.0,p<0.01) demonstrated higher dBIC than NGA(µ=3.2,S.D3.9). At 2W fBIC significant closer to the crest for SLActive(µ=-14072,S.D=419.5,p<0.01) and SLA(µ=-1971.5,S.D=590.6,p<0.05) compared to NGA(µ=-2567.1,S.D=416.8). At 8 weeks both SLActive(µ=-461.3,S.D=643.4,p<0.01) and SLA(µ=-652.1,S.D=581.8,p<0.01) fBIC was significantly closer to the crest than NGA(µ=-1633.5,S.D=763.6). At 2W and 8W there was no evidence of a difference(p>0.05) in NBH or BATA between the groups.
Conclusions: At 2 and 8 weeks the SLActive surface compared to NGA demonstrated significantly higher levels of dBIC, fBIC and VBC. SLA surface demonstrated significantly higher levels of fBIC and VBC at 2 weeks and dBIC, fBIC and VBC at 8 weeks compared to the NGA surface.