IADR Abstract Archives
Assessment of Novel Remineralizing GIC and its Behaviour in Artificial Xerostomic Saliva
Objectives: To formulate an artificial salivary composition that simulates xerostomic patient saliva based on a systematic review of the literature and to evaluate the mechanical properties, fluoride release, and remineralization potential of the experimental glass ionomer cement (GIC) containing apatite in normal and xerostomic artificial saliva (AS).
Methods: Based on a systematic search of the literature, AS was formulated to represent patients with xerostomia. The xerostomic and a non-xerostomic AS were used for the immersion of the experimental GIC and Fuji IX control cements. The experimental cements were made using three groups of Fluro-alumina-silicate glass with varied fraction of apatite induced on glass heat treatment (non-heat-treated, heat-treated at Tg+50, and heat-treated at Tg+80). Compressive strength and fluoride release of each group were tested at six-time points. MAS-NMR analysis was carried out on crushed cement powder.
Results: Cement samples of all formulations including the commercial had significantly higher release of Fluoride when stored in xerostomic saliva in comparison to non-xerostomic saliva across all time periods. The experimental cements with the Tg+80 heat treatment glass resulted in significantly higher compressive strength compared to the cements with non-heat-treated glass. In addition, the compressive strength of all experimental cement groups has mainly enhanced with time with the Tg+80 cements the compressive strength progressively increased at every long-term duration point. In 31P MAS-NMR spectra of these cements substantial amount of apatite crystals was revealed which were present at all immersion points and the fraction of apatite phase did not decrease with time.
Conclusions: The cements with a substantial amount of apatite phase revealed the most beneficial properties that can be further optimized to the level of the commercial formulations. These experimental formulations will deliver improved remineralization in clinical applications particularly where it is most needed in high-risk xerostomic patients.
Methods: Based on a systematic search of the literature, AS was formulated to represent patients with xerostomia. The xerostomic and a non-xerostomic AS were used for the immersion of the experimental GIC and Fuji IX control cements. The experimental cements were made using three groups of Fluro-alumina-silicate glass with varied fraction of apatite induced on glass heat treatment (non-heat-treated, heat-treated at Tg+50, and heat-treated at Tg+80). Compressive strength and fluoride release of each group were tested at six-time points. MAS-NMR analysis was carried out on crushed cement powder.
Results: Cement samples of all formulations including the commercial had significantly higher release of Fluoride when stored in xerostomic saliva in comparison to non-xerostomic saliva across all time periods. The experimental cements with the Tg+80 heat treatment glass resulted in significantly higher compressive strength compared to the cements with non-heat-treated glass. In addition, the compressive strength of all experimental cement groups has mainly enhanced with time with the Tg+80 cements the compressive strength progressively increased at every long-term duration point. In 31P MAS-NMR spectra of these cements substantial amount of apatite crystals was revealed which were present at all immersion points and the fraction of apatite phase did not decrease with time.
Conclusions: The cements with a substantial amount of apatite phase revealed the most beneficial properties that can be further optimized to the level of the commercial formulations. These experimental formulations will deliver improved remineralization in clinical applications particularly where it is most needed in high-risk xerostomic patients.