IADR Abstract Archives
A Novel Bioactive Resin Infiltrant for Early Enamel Carious Lesions
Objectives: Resin infiltration is an effective microinvasive treatment for early non-cavitated enamel carious lesions. The current commercial material depends on complete infiltration and sealing of the lesion. As the material is non-bioactive, any leakage will lead to secondary caries formation. The aim of the present project was to develop a bioactive resin infiltrant with the potential of remineralization.
Methods: A fluoridated bioactive glass (FBAG), composed of silicon dioxide (SiO2, 35.25 mol%), phosphorus pentoxide (P2O5, 5.75 mol%), calcium carbonate (CaCO3, 43 mol%), sodium carbonate (Na2CO3, 6 mol%), and calcium fluoride (CaF2, 10 mol%)), was prepared using a melt quench technique and milled to produce glass particles of 35µm. FBAG was mixed with an experimental infiltrant (EI, 80% triethylene-glycol dimethacrylate and 20% urethane dimethacrylate) at a weight% ration of 30:70 respectively. Ten human permanent teeth with artificial carious lesions on their proximal surfaces were infiltrated with this infiltrant. Five teeth were immersed in pH=4 while the other in pH=7 solutions. Calcium and fluoride ion release in both media were measured using an ion selective electrode and the pH was monitored using a pH meter. Readings were recorded over 12 weeks.
Results: Both calcium and fluoride release were higher in the acidic solution over the entire period than in the neutral solution. While the calcium concentration increased with time in both solutions, the fluoride ions decreased as pH increased in the acidic solution, indicating formation of calcium fluoride or fluorapatite.
Conclusions: The bioactive infiltrant has the potential to release beneficial ions to neutralize acidic challenge to return an environment that is suitable for remineralization.
Methods: A fluoridated bioactive glass (FBAG), composed of silicon dioxide (SiO2, 35.25 mol%), phosphorus pentoxide (P2O5, 5.75 mol%), calcium carbonate (CaCO3, 43 mol%), sodium carbonate (Na2CO3, 6 mol%), and calcium fluoride (CaF2, 10 mol%)), was prepared using a melt quench technique and milled to produce glass particles of 35µm. FBAG was mixed with an experimental infiltrant (EI, 80% triethylene-glycol dimethacrylate and 20% urethane dimethacrylate) at a weight% ration of 30:70 respectively. Ten human permanent teeth with artificial carious lesions on their proximal surfaces were infiltrated with this infiltrant. Five teeth were immersed in pH=4 while the other in pH=7 solutions. Calcium and fluoride ion release in both media were measured using an ion selective electrode and the pH was monitored using a pH meter. Readings were recorded over 12 weeks.
Results: Both calcium and fluoride release were higher in the acidic solution over the entire period than in the neutral solution. While the calcium concentration increased with time in both solutions, the fluoride ions decreased as pH increased in the acidic solution, indicating formation of calcium fluoride or fluorapatite.
Conclusions: The bioactive infiltrant has the potential to release beneficial ions to neutralize acidic challenge to return an environment that is suitable for remineralization.