IADR Abstract Archives
Characterization of Bioactive Restorative Materials for Restoration of Root Caries
Objectives: Restoration of root surface carious lesions is challenging due to the heterogenicity of the substrate to which the material needs to be bonded to. Furthermore, the material needs to have specific characteristics and thus be both antimicrobial and also encourage periodontal tissue regeneration. The aim of this study was to develop and characterize novel bioactive materials that can prevent biofilm adhesion.
Methods: Three commercial resin-based materials and two prototypes with a hydrophilic resin matrix incorporating a Sr or 45S5 bioglass were tested. The set materials were characterized using scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) analysis. Surface characterization was performed by SEM-EDS, profilometry, and contact angle measurements after immersion in Hank’s balanced salt solution at different time periods. The degree of conversion (DC) was evaluated for the tested materials using FTIR-ATR method. Material eluates were assessed for ion release and pH.
Results: Both prototypes exhibited a significantly higher DC, pH and release of Sr, Ca and Si in the solution which was maintained over the testing period. SEM-EDS analysis revealed cracks in the interface between fillers and matrix as well as within the filler particles after immersion. The roughest surface was observed in the Sr-prototype which was significantly higher than the other tested materials. For the contact angle measurements, RMGI and both prototypes were the most hydrophilic among the studied materials. The KBr-FTIR analysis of the prototypes revealed that with the increase in the immersion period, peaks related to the polymer matrix decreased in intensity while bands corresponded to PO4 increased and sharpened.
Conclusions: The novel composite materials exhibit promising bioactive and wetting properties; however further optimization is necessary to improve filler to resin interaction and to tailor make these materials to be both antimicrobial and enhance periodontal tissue regeneration.
Methods: Three commercial resin-based materials and two prototypes with a hydrophilic resin matrix incorporating a Sr or 45S5 bioglass were tested. The set materials were characterized using scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) analysis. Surface characterization was performed by SEM-EDS, profilometry, and contact angle measurements after immersion in Hank’s balanced salt solution at different time periods. The degree of conversion (DC) was evaluated for the tested materials using FTIR-ATR method. Material eluates were assessed for ion release and pH.
Results: Both prototypes exhibited a significantly higher DC, pH and release of Sr, Ca and Si in the solution which was maintained over the testing period. SEM-EDS analysis revealed cracks in the interface between fillers and matrix as well as within the filler particles after immersion. The roughest surface was observed in the Sr-prototype which was significantly higher than the other tested materials. For the contact angle measurements, RMGI and both prototypes were the most hydrophilic among the studied materials. The KBr-FTIR analysis of the prototypes revealed that with the increase in the immersion period, peaks related to the polymer matrix decreased in intensity while bands corresponded to PO4 increased and sharpened.
Conclusions: The novel composite materials exhibit promising bioactive and wetting properties; however further optimization is necessary to improve filler to resin interaction and to tailor make these materials to be both antimicrobial and enhance periodontal tissue regeneration.