IADR Abstract Archives
Hypertension, Calcium Channel Blockers and Risk of Periodontitis.
Objectives: A number of reports have suggested that hypertension is associated with risk of periodontitis. We have previously presented that calcium channel blocker (CCB) medication is independently associated with risk of periodontitis in the NHANES 2011- 12 and PRIME cohorts. Therefore the aim of the study here was to explore this relationship further and to investigate the relative contribution of CCBs and hypertension on risk of periodontitis.
Methods: We extended our previous analyses of the NHANES data to include all subjects over the age of 40 from the NHANES 2009 – 2014 cohort. In separate models we investigated the relationship of CCBs and hypertension with periodontitis, and also investigated this in hypertensive subjects who were not taking CCB medication using logistic regression. The outcome variable was moderate –severe periodontitis ( Page & Eke 2007). Other explanatory variables included in the models were age, gender, race, education, diabetes mellitus, BMI and smoking.
Results: Data from a total of 8104 subjects over the age of 40 were available for analysis. Of these, 52% had moderate-severe periodontitis, 34.9% were hypertensive, and 11.5% were taking CCBs. In Univariate analyses both CCBs and hypertension were associated with Periodontitis ( P<0.001). In fully adjusted models neither CCBs or Hypertension remained significantly associated with periodontitis. Age, race, education, diabetes and smoking were all significantly associated with periodontitis in the fully adjusted models, whereas BMI was not.
Conclusions: The results for CCBs are in contrast with our previous results from analysis of the NHANES 2011-12 cohort only and from analysis of the PRIME dataset. The results do not support the association of hypertension with periodontitis and do however suggest that CCB medication should be considered a potential confounder for the role of hypertension in periodontitis.
Methods: We extended our previous analyses of the NHANES data to include all subjects over the age of 40 from the NHANES 2009 – 2014 cohort. In separate models we investigated the relationship of CCBs and hypertension with periodontitis, and also investigated this in hypertensive subjects who were not taking CCB medication using logistic regression. The outcome variable was moderate –severe periodontitis ( Page & Eke 2007). Other explanatory variables included in the models were age, gender, race, education, diabetes mellitus, BMI and smoking.
Results: Data from a total of 8104 subjects over the age of 40 were available for analysis. Of these, 52% had moderate-severe periodontitis, 34.9% were hypertensive, and 11.5% were taking CCBs. In Univariate analyses both CCBs and hypertension were associated with Periodontitis ( P<0.001). In fully adjusted models neither CCBs or Hypertension remained significantly associated with periodontitis. Age, race, education, diabetes and smoking were all significantly associated with periodontitis in the fully adjusted models, whereas BMI was not.
Conclusions: The results for CCBs are in contrast with our previous results from analysis of the NHANES 2011-12 cohort only and from analysis of the PRIME dataset. The results do not support the association of hypertension with periodontitis and do however suggest that CCB medication should be considered a potential confounder for the role of hypertension in periodontitis.