IADR Abstract Archives
Daily Brushing with Toothpastes Helps Maintain Gingival Health
Objectives: To evaluate the effectiveness of 5% calcium sodium phosphosilicate (CSPS) toothpastes in maintaining gingival health and controlling dental plaque.
Methods: Two sequential, 12-week, randomised (stratified by Modified Gingival Index [MGI] score), controlled, examiner-blind, parallel group studies were conducted in adults with a mean screening MGI score 1.50–2.50, who showed gingival health improvement following prophylaxis and 2 weeks rigorous oral hygiene. Eligible subjects were randomised to study toothpastes. Study 1: (i) 5% CSPS with cocoamidopropyl betaine/sodium methyl cocoyl taurate (CAPB/SMCT) (relative dentine abrasivity [RDA]~160); (ii) 0% CSPS/[CAPB/SMCT] (placebo; RDA~150) or (iii) 923 ppm fluoride as NaF/sodium lauryl sulphate [SLS] (negative control; RDA~90). Study 2: (i) 5% CSPS/SLS (RDA~140); (ii) 5% CSPS/SLS (RDA~100); (iii) 5% CSPS/[CAPB/SMCT] (RDA~100) or (iv) 0% CSPS/SLS (placebo; RDA~100) or v) Study 1 negative control. Study 1 toothpastes (i) and (ii) and all Study 2 toothpastes contained 927 ppm fluoride as sodium monofluorophosphate. Subjects brushed twice daily for 12 weeks. Gingival health and supra-gingival plaque were assessed after 6 and 12 weeks (MGI, Bleeding Index [BI] and Turesky Plaque Index [TPI]).
Results: 148/253 subjects in Study 1/Study 2 formed the intent-to-treat populations. Following prophylaxis, twice daily brushing with all study toothpastes helped maintain gingival health over 12 weeks in both studies, with only small changes in MGI, BI and TPI scores compared with baseline. Overall, observed differences between treatments were small, with few statistically significant (p<0.05) differences. Toothpastes were generally well tolerated. Some instances of ‘oral discomfort’ were reported in both studies, mainly by subjects using CSPS/placebo toothpastes. Non-aqueous formulations are known to produce warming/heating sensations. No oral pathologies were noted in most cases.
Conclusions: Daily brushing with all toothpastes helped maintain gingival health for 12 weeks following prophylaxis. Few between-treatment differences were reported; the 5% CSPS toothpastes provided only comparable benefits to placebo and negative-control.
Methods: Two sequential, 12-week, randomised (stratified by Modified Gingival Index [MGI] score), controlled, examiner-blind, parallel group studies were conducted in adults with a mean screening MGI score 1.50–2.50, who showed gingival health improvement following prophylaxis and 2 weeks rigorous oral hygiene. Eligible subjects were randomised to study toothpastes. Study 1: (i) 5% CSPS with cocoamidopropyl betaine/sodium methyl cocoyl taurate (CAPB/SMCT) (relative dentine abrasivity [RDA]~160); (ii) 0% CSPS/[CAPB/SMCT] (placebo; RDA~150) or (iii) 923 ppm fluoride as NaF/sodium lauryl sulphate [SLS] (negative control; RDA~90). Study 2: (i) 5% CSPS/SLS (RDA~140); (ii) 5% CSPS/SLS (RDA~100); (iii) 5% CSPS/[CAPB/SMCT] (RDA~100) or (iv) 0% CSPS/SLS (placebo; RDA~100) or v) Study 1 negative control. Study 1 toothpastes (i) and (ii) and all Study 2 toothpastes contained 927 ppm fluoride as sodium monofluorophosphate. Subjects brushed twice daily for 12 weeks. Gingival health and supra-gingival plaque were assessed after 6 and 12 weeks (MGI, Bleeding Index [BI] and Turesky Plaque Index [TPI]).
Results: 148/253 subjects in Study 1/Study 2 formed the intent-to-treat populations. Following prophylaxis, twice daily brushing with all study toothpastes helped maintain gingival health over 12 weeks in both studies, with only small changes in MGI, BI and TPI scores compared with baseline. Overall, observed differences between treatments were small, with few statistically significant (p<0.05) differences. Toothpastes were generally well tolerated. Some instances of ‘oral discomfort’ were reported in both studies, mainly by subjects using CSPS/placebo toothpastes. Non-aqueous formulations are known to produce warming/heating sensations. No oral pathologies were noted in most cases.
Conclusions: Daily brushing with all toothpastes helped maintain gingival health for 12 weeks following prophylaxis. Few between-treatment differences were reported; the 5% CSPS toothpastes provided only comparable benefits to placebo and negative-control.