IADR Abstract Archives
Reducing Dentinal Hypersensitivity Improves Oral Health-Related Quality of Life
Objectives: To investigate the impact of long-term management of dentine hypersensitivity (DH) on oral hygiene and oral health-related quality of life (OHRQoL).
Methods: This was a 24-week, non-comparative, exploratory, clinical study conducted in healthy adults with clinically confirmed dentine hypersensitivity. Subjects brushed twice daily for 24 weeks with an anti-hypersensitivity toothpaste containing 5% calcium sodium phosphosilicate (CSPS) and 1426 ppm fluoride as sodium monofluorophosphate. DH was assessed at intervals over the study period in response to an evaporative (air) stimulus (Schiff sensitivity score; Labelled Magnitude Scales for Intensity, Duration, Tolerability and Description of sensation; number of sensitive teeth) and a tactile (Yeaple probe) stimulus. Supra-gingival plaque and gingival health were monitored using the Turesky Plaque Index (TPI) and the Modified Gingival Index (MGI), respectively. Subject-perceived OHRQoL was evaluated using the Dentine Hypersensitivity Experience Questionnaire (DHEQ).
Results: Seventy-five subjects were included in the safety and intent-to-treat analysis populations. All sensitivity measures demonstrated ongoing reductions in DH compared with baseline over the 24-week treatment period. Mean TPI scores decreased for sensitive teeth, and were lower than the mean whole-mouth scores, throughout the study; MGI scores were unchanged. All DHEQ measures, with the exception of the global oral health rating, demonstrated ongoing improvements in OHRQoL across the extended study period. Improvements in DH were statistically significantly (p<0.05) correlated with improvements in DHEQ measures for a number of DHEQ summary measures and DH measures. No correlations were seen between changes in DH and plaque accumulation. The study treatment was generally well tolerated.
Conclusions: Twice-daily brushing with a 5% CSPS toothpaste reduced DH across the 24-week study period. The ongoing, clinically significant improvements in DH were associated with improved OHRQoL. The results did not indicate a relationship between DH and oral hygiene.
Methods: This was a 24-week, non-comparative, exploratory, clinical study conducted in healthy adults with clinically confirmed dentine hypersensitivity. Subjects brushed twice daily for 24 weeks with an anti-hypersensitivity toothpaste containing 5% calcium sodium phosphosilicate (CSPS) and 1426 ppm fluoride as sodium monofluorophosphate. DH was assessed at intervals over the study period in response to an evaporative (air) stimulus (Schiff sensitivity score; Labelled Magnitude Scales for Intensity, Duration, Tolerability and Description of sensation; number of sensitive teeth) and a tactile (Yeaple probe) stimulus. Supra-gingival plaque and gingival health were monitored using the Turesky Plaque Index (TPI) and the Modified Gingival Index (MGI), respectively. Subject-perceived OHRQoL was evaluated using the Dentine Hypersensitivity Experience Questionnaire (DHEQ).
Results: Seventy-five subjects were included in the safety and intent-to-treat analysis populations. All sensitivity measures demonstrated ongoing reductions in DH compared with baseline over the 24-week treatment period. Mean TPI scores decreased for sensitive teeth, and were lower than the mean whole-mouth scores, throughout the study; MGI scores were unchanged. All DHEQ measures, with the exception of the global oral health rating, demonstrated ongoing improvements in OHRQoL across the extended study period. Improvements in DH were statistically significantly (p<0.05) correlated with improvements in DHEQ measures for a number of DHEQ summary measures and DH measures. No correlations were seen between changes in DH and plaque accumulation. The study treatment was generally well tolerated.
Conclusions: Twice-daily brushing with a 5% CSPS toothpaste reduced DH across the 24-week study period. The ongoing, clinically significant improvements in DH were associated with improved OHRQoL. The results did not indicate a relationship between DH and oral hygiene.