IADR Abstract Archives
Choice of Toothpaste Surfactant System Influences Plaque Regrowth
Objectives: To evaluate the efficacy of an experimental toothpaste containing 5% (w/w) calcium sodium phosphosilicate (CSPS) and a modified surfactant system in preventing
24-hour plaque regrowth.
Methods: Two sequential exploratory, randomised, controlled, four-treatment, four-period crossover, single-use (on clean and non-clean tooth surfaces), examiner-blind studies were conducted in healthy adult subjects with individual mean whole-mouth Turesky Plaque Index (TPI) scores ≥2.0. In both studies, the experimental toothpaste contained 5% (w/w) CSPS, 927 ppm fluoride as sodium monofluorophosphate (SMFP) and a cocamidopropyl betaine/sodium methyl cocoyl taurate (CAPB/SMCT) surfactant system (relative dentine abrasivity [RDA] ~160). Efficacy was compared with that of: (i) two marketed comparator toothpastes (both 5% CSPS, 1426 ppm fluoride as SMFP, sodium lauryl sulphate [SLS] surfactant [one with RDA ~100 in both studies; one with RDA ~140 in Study 2]); (ii) a placebo toothpaste (0% CSPS, 927 ppm fluoride as SMFP, CAPB/SMCT surfactant; RDA ~150) (Study 1); and (iii) a marketed control toothpaste (1450 ppm fluoride as NaF, SLS surfactant, RDA ~90) (both studies). Following supragingival prophylaxis, subjects brushed with the study toothpastes on two occasions per treatment period to evaluate efficacy on clean tooth surfaces on Day 1, non-clean surfaces on Day 2. Plaque regrowth was measured 24 hours after each brushing using the TPI and Gingival Margin Plaque Index.
Results: Overall, 37 subjects in Study 1 and 36 subjects in Study 2 were included in the efficacy (intent-to-treat) and safety populations. In both studies, plaque regrowth after 24 hours was consistently lower (statistically significant differences or numerical trends depending on measure and comparison) for the SLS-containing toothpastes compared with the CAPB/SMCT-containing toothpastes, on both clean and non-clean tooth surfaces, with both plaque measures. Treatments were generally well tolerated.
Conclusions: The SLS surfactant system appears to contribute to the slowing of plaque regrowth after brushing with CSPS-containing toothpastes.
24-hour plaque regrowth.
Methods: Two sequential exploratory, randomised, controlled, four-treatment, four-period crossover, single-use (on clean and non-clean tooth surfaces), examiner-blind studies were conducted in healthy adult subjects with individual mean whole-mouth Turesky Plaque Index (TPI) scores ≥2.0. In both studies, the experimental toothpaste contained 5% (w/w) CSPS, 927 ppm fluoride as sodium monofluorophosphate (SMFP) and a cocamidopropyl betaine/sodium methyl cocoyl taurate (CAPB/SMCT) surfactant system (relative dentine abrasivity [RDA] ~160). Efficacy was compared with that of: (i) two marketed comparator toothpastes (both 5% CSPS, 1426 ppm fluoride as SMFP, sodium lauryl sulphate [SLS] surfactant [one with RDA ~100 in both studies; one with RDA ~140 in Study 2]); (ii) a placebo toothpaste (0% CSPS, 927 ppm fluoride as SMFP, CAPB/SMCT surfactant; RDA ~150) (Study 1); and (iii) a marketed control toothpaste (1450 ppm fluoride as NaF, SLS surfactant, RDA ~90) (both studies). Following supragingival prophylaxis, subjects brushed with the study toothpastes on two occasions per treatment period to evaluate efficacy on clean tooth surfaces on Day 1, non-clean surfaces on Day 2. Plaque regrowth was measured 24 hours after each brushing using the TPI and Gingival Margin Plaque Index.
Results: Overall, 37 subjects in Study 1 and 36 subjects in Study 2 were included in the efficacy (intent-to-treat) and safety populations. In both studies, plaque regrowth after 24 hours was consistently lower (statistically significant differences or numerical trends depending on measure and comparison) for the SLS-containing toothpastes compared with the CAPB/SMCT-containing toothpastes, on both clean and non-clean tooth surfaces, with both plaque measures. Treatments were generally well tolerated.
Conclusions: The SLS surfactant system appears to contribute to the slowing of plaque regrowth after brushing with CSPS-containing toothpastes.