IADR Abstract Archives
Brushing with Toothpaste Containing 5% CSPS Reduces Dental Plaque
Objectives: To evaluate the effectiveness in controlling plaque of a toothpaste containing 5% calcium sodium phosphosilicate (CSPS).
Methods: A 4-week, randomised (stratified by baseline plaque score), controlled, examiner-blind, parallel-group clinical study was conducted in healthy adults with a mean Turesky Plaque Index (TPI) score ≥2.0 (assessed at baseline, 24 hours after last oral hygiene). Eligible subjects were randomised to: (i) an experimental toothpaste containing 5% CSPS and cocamidopropyl betaine/sodium methyl cocoyl taurate (CAPB/SMCT) (relative dentine abrasivity [RDA] ~160; 927 ppm fluoride as sodium monofluorophosphate [SMFP]); (ii) a 0% CSPS, CAPB/SMCT toothpaste (RDA ~150; 927 ppm fluoride as SMFP); or (iii) a regular fluoride/sodium lauryl sulphate toothpaste (negative control; RDA ~90; 1450 ppm fluoride as sodium fluoride). They were instructed to brush with their allocated toothpaste twice daily for 4 weeks. Supra-gingival plaque (TPI) was re-assessed after 2 and 4 weeks of treatment, and before and after single brushings carried out at the baseline and Week 4 visits.
Results: A total of 168 subjects were included in the intent-to-treat analysis population. At Week 4 (primary endpoint), all study treatments demonstrated small but statistically significant reductions from baseline in mean TPI scores (p<0.05); no statistically significant between-treatment differences were detected. All treatments showed statistically significant within-treatment reductions in TPI scores after a single brushing (p<0.0001, baseline and Week 4), with only one statistically significant between-treatment difference detected (in favour of placebo; p<0.0474, Week 4 only). Study treatments were generally well tolerated.
Conclusions: Brushing with a toothpaste containing 5% CSPS reduced supra-gingival plaque levels and provided plaque-removal efficacy comparable with that of an abrasivity-matched placebo and a regular fluoride toothpaste.
Methods: A 4-week, randomised (stratified by baseline plaque score), controlled, examiner-blind, parallel-group clinical study was conducted in healthy adults with a mean Turesky Plaque Index (TPI) score ≥2.0 (assessed at baseline, 24 hours after last oral hygiene). Eligible subjects were randomised to: (i) an experimental toothpaste containing 5% CSPS and cocamidopropyl betaine/sodium methyl cocoyl taurate (CAPB/SMCT) (relative dentine abrasivity [RDA] ~160; 927 ppm fluoride as sodium monofluorophosphate [SMFP]); (ii) a 0% CSPS, CAPB/SMCT toothpaste (RDA ~150; 927 ppm fluoride as SMFP); or (iii) a regular fluoride/sodium lauryl sulphate toothpaste (negative control; RDA ~90; 1450 ppm fluoride as sodium fluoride). They were instructed to brush with their allocated toothpaste twice daily for 4 weeks. Supra-gingival plaque (TPI) was re-assessed after 2 and 4 weeks of treatment, and before and after single brushings carried out at the baseline and Week 4 visits.
Results: A total of 168 subjects were included in the intent-to-treat analysis population. At Week 4 (primary endpoint), all study treatments demonstrated small but statistically significant reductions from baseline in mean TPI scores (p<0.05); no statistically significant between-treatment differences were detected. All treatments showed statistically significant within-treatment reductions in TPI scores after a single brushing (p<0.0001, baseline and Week 4), with only one statistically significant between-treatment difference detected (in favour of placebo; p<0.0474, Week 4 only). Study treatments were generally well tolerated.
Conclusions: Brushing with a toothpaste containing 5% CSPS reduced supra-gingival plaque levels and provided plaque-removal efficacy comparable with that of an abrasivity-matched placebo and a regular fluoride toothpaste.