Socioeconomic Risk Factors Associated with Upper Aerodigestive Tract Cancer
Objectives: Socioeconomic inequalities in upper aerodigestive tract (UADT) cancers are recognised across the world. We aimed to assess the components of socioeconomic risk both independently and through their influence on the known behavioural risk factors of smoking, alcohol consumption, and diet.
Methods: A multicenter case-control study with 2285 cases of UADT cancer and 2216 controls from hospital and population sources. Personal interviews collected information on demographics, and lifetime occupation history, smoking, alcohol consumption, and diet. Socioeconomic status was measured by education, occupational social class, and unemployment.
Results: Odds ratios (OR) and 95% Confidence Intervals (CI) were computed using unconditional logistic regression and multivariate analyses. When controlling for age, sex, and center significantly increased risks for UADT cancer were observed for those with low vs high educational attainment OR = 1.95 (95% CI 1.64, 2.31). Similarly, for occupational socioeconomic indicators – comparing the lowest vs highest International Socioeconomic Index (ISEI) quartile for the longest occupation gave OR = 1.55 (1.24, 1.93); and for unemployment OR = 1.60 (1.21, 2.11). Statistical significance remained for low education when adjusting for smoking, alcohol, and diet behaviours OR = 1.29 (1.06, 1.57) in the multivariate analysis. Associations were consistent for subsite and source of controls (hospital and community).
Conclusions: Socioeconomic inequalities observed for these cancers are not totally explained by smoking, alcohol, and diet.
Division: British Division Meeting
Meeting:2009 British Division Meeting (Glasglow, Scotland) Location: Glasglow, Scotland
Year: 2009 Final Presentation ID:29 Abstract Category|Abstract Category(s):Scientific Groups
Authors
Conway, David I.
( University of Glasgow, Glasgow, N/A, United Kingdom
)
Lagiou, Pagona
( University of Athens, Athens, N/A, Greece
)
Minaki, Ploumitsa
( University of Athens, Athens, N/A, Greece
)
Bencko, Vladimir
( Charles University in Prague, Prague, N/A, Czech Republic
)
Holcatova, Ivana
( Charles University in Prague, Prague, N/A, Czech Republic
)
Merletti, Franco
( University of Turin, Turin, N/A, Italy
)
Richiardi, Lorenzo
( University of Turin, Turin, N/A, Italy
)
Kjaerheim, Kristina
( Cancer Registry of Norway, Oslo, N/A, Norway
)
Agudo, Antonio
( Catalan Institute of Oncology, Barcelona, N/A, Spain
)
Castellsagué, Xavier
( Catalan Institute of Oncology, Barcelona, N/A, Spain
)
Talamini, Renato
( Centro di Riferimento Oncologico (IRCCS), Aviano, N/A, Italy
)
Mckinney, Patricia A.
( University of Leeds, Leeds, N/A, United Kingdom
)
Barzan, Luigi
( Ospedale S. Maria Degli Angeli, Pordenone, N/A, Italy
)
Canova, Cristina
( University of Padova, Padova, N/A, Italy
)
Simonato, Lorenzo
( University of Padova, Padova, N/A, Italy
)
Lowry, Ray
( University of Newcastle, Newcastle, N/A, United Kingdom
)
Znaor, Ariana
( Croatian National Cancer Registry, Zagreb, N/A, Croatia
)
Healy, Claire
( Dublin Dental School and Hospital, Dublin, N/A, Ireland
)
Mccartan, Bernard E.
( Dublin Dental School and Hospital, Dublin, N/A, Ireland
)
Marron, Manuela
( International Agency for Research on Cancer, Lyon, N/A, France
)
Hashibe, Mia
( International Agency for Research on Cancer, Lyon, N/A, France
)
Brennan, Paul
( International Agency for Research on Cancer, Lyon, N/A, France
)
Mcmahon, Alex D.
( University of Glasgow, Glasgow, N/A, United Kingdom
)
Ahrens, Wolfgang
( Bremen Institute for Prevention Research and Social Medicine, Bremen, N/A, Germany
)
Schmeisser, Nils
( Bremen Institute for Prevention Research and Social Medicine, Bremen, N/A, Germany
)
Benhamou, Simone
( INSERM, Paris, N/A, France
)
Bouchardy, Christine
( Geneva Cancer Registry, Geneva, N/A, Switzerland
)
Macfarlane, Gary
( University of Aberdeen, Aberdeen, N/A, United Kingdom
)
Macfarlane, Tatiana
( University of Aberdeen, Aberdeen, N/A, United Kingdom
)
SESSION INFORMATION
Oral Session
Junior and Senior Colgate Prizes
09/02/2009