Objective: This in-vitro study investigated the durability of shear bond strength (SBS) of recently introduced luting agents to human dentin. Methods: One-hundred and twelve lower molars were stored in 1% Thymol solution. The occlusal surface was prepared to a flat dentin surface. The molars were divided into six groups each of 20 specimens. Translucent plastic rings were filled with the following luting agents and luted to the prepared specimens, self-adhesive compomer luting cement (CLC, Dyract® Cemplus, Dentsply DeTrey, Germany), hybrid glass ionomer cement in past form, (HGI, Fuji CEM, GC Corporation, J) and conventional glass ionomer, (CGI, Meron, Cuxhaven, Germany). Bonding procedures were created according to the manufacturer instructions for each luting agent. One day after luting,10 specimens of each group were stored in water bath for 24 hours. The other 10 specimens of each group were stored in water bath for 3 months and thermocycled for 10000 cycles. Shear force was applied to each specimen at the junction of the plastic ring/dentin interface using a knife-edge rod at a cross head speed of 0.5mm/min in a universal testing machine. Kruskal-Wallis and Mann-Whitney tests at p
£ 0.05 were used for statistical analysis. Results: Mean (SBS) in MPa before and after thermalcycling are CLC, (20.8±3.6, 12.9±2.8); HGI, (21.6±4.1, 14.7±2.7) and CGI, (17.3 ±3.2, 9.2 ±2.4). There was no statistically significant difference in the mean SBS of CLC and GIP before and after storage in water and thermalcycling, however mean SBS of CLC and HGI was significantly higher than mean SBS of CGI before and after thermalcycling. On the other hand long term storage in water and thermalcycling significantly decreased SBS of CLC, HGI and CGI to human dentin. Conclusion: Hybrid glass ionomer and self-adhesive compomer luting cements are prefered for luting indirect restorations.