Global burden of oral and oropharyngeal diseases in 2010 as reflected in Cochrane Database of Systematic Reviews

Objectives: The purpose of this study is to analyze the Cochrane Database of Systematic Reviews (CDSR) and determine whether oral disease related systematic reviews and protocols represent disease burden, as measured by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 Project.
Methods: Eight conditions have been identified in the GBD 2010 project as relevant to oral and oropharyngeal disease. The conditions were ranked based on % of total DALYs (disability-adjusted life years). Upon reviewing search results within CDSR, systematic reviews and protocols were matched to oral diseases based on subject content and study objectives. In order to be included, a review/ protocol must have included the oral disease as a predominant focus of the subject content.
Results: The condition were ranked in order of decreasing (esophageal cancer, edentulsim, dental caries, periodontal disease, mouth cancer, Cancer of the other part of pharynx and oropharynx, Nasopharynx cancer, Cleft Lip and Cleft Palate). All conditions are represented with at least one systematic review and one protocol in the library. Edentulism had higher % total 2010 Daly compared to periodontal diseases but has been less represented in the Cochrane library (11 versus 13) and clinical trials included in the reviews (87 versus 101 trials).
Conclusions: Edentulism was proportionally under-represented in the CDSR. This also reflected in the number of clinical trials included in each reviews. We will be also looking at mapping CDSR against 2010 DALY rank and median percentage change in DALY from 1990-201. These results provide high-quality and transparent data that may guide future prioritization decisions.The project is part of a larger project mapping the CDSR again Global Burden of Disease 2010.