Trends Of Oral Cavity, Oropharyngeal, And Laryngeal Cancer Incidence In Scotland (2001- 2012).

Objectives: To assess the current incidence burden of oropharyngeal (OPC), oral cavity (OCC), and laryngeal cancer in Scotland, and examine the factors influencing trends between 2001 and 2012.
Methods: Our study included all diagnosed cases of OCC (C00.3-C00.9, C02-C06 excluding C2.4), OPC (C01, C2.4, C09-C10, C14), and larynx (C32), registered at the Scottish Cancer Registry between 2000 and 2012. We collated annual midterm population estimates by age, sex, Scottish Index of Multiple Deprivation (SIMD), and region. Age-standardized rates and fully adjusted Poisson regression rate-ratios (RR) were used to compare all subsites, by age, sex, region, SIMD, and year of diagnosis. All statistical analyses were performed using SAS 9.3, and level of significance was fixed at 0.05.
Results: The fully adjusted Poisson regression model showed that males exhibited significantly higher rates of OPC (RR 3.31; 95% Confidence Interval (CI) 3.02-3.62) and OCC (RR 1.82; 95% CI 1.71-1.94) compared to females. The peak age of incidence of OPC was slightly lower (61-65 years) than the other sub-sites (71 -75 years). Between 2001 and 2012, there was a two-fold increase in rates of OPC (RR 1.85; 95% CI 1.53-2.25), rates off OCC were seen to plateau, and rates of laryngeal cancer decreased (RR 0.77; 95% CI 0.65-0.90). The most socioeconomically deprived areas had the highest rates of OPC (RR 3.33, 95% CI 2.72-4.07), OCC (RR 2.69, 95% CI 2.31-3.13), and laryngeal cancer (RR 4.98, 95% CI 4.15-5.97), and an almost dose-like response was observed with increasing deprivation increasing cancer risk.
Conclusions: In Scotland in the decade to 2012, the incidence rates of OPC rose, while OCC were stable and laryngeal cancer decreased. The highest rates of cancer were seen in males in the 60-75 year age group and those from the most deprived areas.