Corrosion is a potential cause of implant failure both in Dentistry and Orthopedics. The identification in tissues of metal particles that result from the corrosion process can be performed by different methods such as light microscopy, microincineration and/or electron microscopy, among others. The characterization of the particle surface has become increasingly important in the field of micro and nanotechnology. Image analysis programs allow for the study of particles in terms of different morphometric parameters that would contribute to establish particle effect in tissues. The aim of the present study was to present a method to evaluate metal particles quantitatively and morphometrically in histological sections of tissues. Software was developed “ad hoc” to quantify the following parameters: number, area, perimeter, volume and surface of the particles. We assessed three samples of human oral mucosa that had been in contact with the closure screw of an implant (implant lid) and showed histological evidence of metal particles. Three areas were selected for measurement: epithelial surface (A), subepithelial connective tissue (B) and connective tissue associated to the implant lid (C). The samples were evaluated in an MPM 800 Zeiss microscope, with the objective X40, NA 0.75. Images of the different selected areas were captured and analyzed with the software developed “ad hoc”. Mean particle area was: sector A 1.37μ (51 particles), sector B 5.14μ (17 particles) and sector C 5.03μ (61 particles). Particle surface was: sector A 6.07μ, sector B 22.90 and sector C 23.86μ. Particle volume was: sector A 1.57, sector B 14.12 and sector C 28.31. Preliminary data are presented on different particle features (quantitative and morphometric) that might influence tissue response. Grants: ANP CyT 33493, UBACyT O006, Fundación Roemmers