IADR Abstract Archives
Practical use and laboratory controls of ortho-phthalaldehyde (OPA) in Dentistry with occupational personal reactive to aldehydes
Biosafety – ortho-phthalaldehyde – occupational exposures
The necessity for appropriate disinfection procedures has been emphasized by professionals and workers in dentistry clinic. Glutaraldehyde is the most commonly used high-level disinfectant for reprocessing dental instrument because of its favorable materials compatibility. However, it is a toxic and irritant chemical, a moderate sensitizer of human skin, causes occupational asthma and rhinitis upon exposure. OPA (ortho-phthalaldehyde) is an organic, aromatic compound that received clearance by the Food and Drug Administration (FDA) in October 1999 to be used as a high-level disinfectant. There are no many reports in Argentine, because his as been recently introduced. The goal of this study it was to evaluated Cidex® OPA (Johnson & Johnson Co) with indigenes strains –Pseudomonas aeruginosa (Pa), Escherichia coli (Ec), Serratia marcescens (Sm), Acinetobacter baumanii (Ab), Candida albicans (Ca), Candida parapsilopsis (Cp)- by Kelsey & Sykes method and to verify the security of the health personnel of Dentistry School, National University of Rosario (Argentine). Results, in use concentrations, 0,55%, without organic matter, for all the evaluated strains, it was effective with high safety margin. However, with organic matter, when facing to Pa it was also effective but without safety margin, for the other strains OPA was lethal with safety margin. In the course of 6 months no personnel showed toxicity signs. We concluded, OPA, in Vitro, is a high-level disinfectant solution in front of local strains, and it has not displayed adverse effects
The necessity for appropriate disinfection procedures has been emphasized by professionals and workers in dentistry clinic. Glutaraldehyde is the most commonly used high-level disinfectant for reprocessing dental instrument because of its favorable materials compatibility. However, it is a toxic and irritant chemical, a moderate sensitizer of human skin, causes occupational asthma and rhinitis upon exposure. OPA (ortho-phthalaldehyde) is an organic, aromatic compound that received clearance by the Food and Drug Administration (FDA) in October 1999 to be used as a high-level disinfectant. There are no many reports in Argentine, because his as been recently introduced. The goal of this study it was to evaluated Cidex® OPA (Johnson & Johnson Co) with indigenes strains –Pseudomonas aeruginosa (Pa), Escherichia coli (Ec), Serratia marcescens (Sm), Acinetobacter baumanii (Ab), Candida albicans (Ca), Candida parapsilopsis (Cp)- by Kelsey & Sykes method and to verify the security of the health personnel of Dentistry School, National University of Rosario (Argentine). Results, in use concentrations, 0,55%, without organic matter, for all the evaluated strains, it was effective with high safety margin. However, with organic matter, when facing to Pa it was also effective but without safety margin, for the other strains OPA was lethal with safety margin. In the course of 6 months no personnel showed toxicity signs. We concluded, OPA, in Vitro, is a high-level disinfectant solution in front of local strains, and it has not displayed adverse effects