BENIGN PENPHIGOID OF MEMBRANA MUCOSAL MEMBRANE (PBMM): TWO CASE REPORTS WITH INAPROPIATED DIAGNOSIS

Introduction:  PBMM or  cicatricial penphigoid is an  autoimmun desease with subepithelial blisters evolution that involved  oral mucosa and eyes. Diagnostic seems to be problematic because  poor  immunologic evaluation, most of the time. It can be presented as   descamativ gingivitis wich is  persistent and  limited to some   adherent gíngival areas (similar to OLP, pènphigo vulgar, psoriasis and discoid eritemathous Lupus), .Objective: to confirm criterial diagnosis aplying to two case reports. Material and Methods ; by clinic observation , histology  ,  immunohistochemical  and immunofluorescence analyses  there were  studied two patiens, masculin ad  femenin, with another autoimmune desease history and previous  diagnòstics of oral lesions. Case 1 (women, 64years old, with  reumathoid artritis and  blistern localized on lips, oral mucosa ,both sides and palate. Previously there were   diagnosticated as recidivant afthous ulcers.Caso 2, man , surgeon, wth oral  liquen  (previous diagnose)  , and ignored descamative  gingivitis  .Some biopsies were performed o both cases.. Results: 1- By histology . diagnostic  of subepithelial blisterns was confirm on both cases. .. 2- Case 1: hihg IgG y C3 ,reumatogram and colagenogram + ( reactive C protein  ).Case 2:  subepitelial blistern and   abundant  leucocitary infiltration  was observed. Immunofluorescence was negative and   Laminin immunomarcation was positive.  .  Antinuclear antibodies (ANCA) +. Immunofluorescence negative. Conclusions: 1- It were confirmed the histoligical patrons  of concense for PBMM  . 2- Inmunofluorescence was negative on both cases because lesions were on first steps of illnes  .In that case it was taken   an alternative  parameter as Laminin which was +..3- Its important diagnostic  in relationship with profession on the second case. were ofthalmologic evaluation was indicated as prevention.
Palabras claves : penphigoid -  descamativ gingivitis- reumathogram-colagenogram-ANCA –immunofluorescence.-Laminin