There are still major challenges to be overcome for engineering large tissue constructs ready for implantation into the human body. These challenges might be biological, ethical or may relate to requirements for Good Manufacturing Practices. At the end of the day the clinical feasibility of any procedure or material will determine if any regenerative medical practitioner will use such technology.
Method: This presentation will revisit the core aspects and bottlenecks of tissue engineering and show cases where a translation into clinical practice has been successful in an area of in vivo bone tissue engineering (ENDOCULTIVATION).
Result:
Tissue engineering of complex structures has entered clinical practices but still remains experimental in various aspects.
Conclusion:
Further research is mandatory to to improve tissue engineering protocols to align with clinical requirments.