Objectives: Computer use in recent time has transformed information and data handling in all fields of endeavour to simplest form in the areas of access, storage, retrieval, analysis and dissemination. With the use of computer soft ware for generation of statistic analysis, the world is fast turning into a global village with the tremendous shift to information and communications technology (ICT) in the field of research. This survey therefore was carried out to assess the level of knowledge and utilization of computer software for statistical analysis among dental researchers in eastern Nigeria. Methods: Questionnaires on the use of computer software for statistical analysis were randomly distributed to 65 practicing dental surgeons of above 5 years experience in the tertiary academic hospitals in eastern Nigeria. The focus was on: years of clinical experience; research work experience; knowledge and application of computer generated software for data processing and statistical analysis. Results: Sixty-two (95.4%) of these questionnaires were returned anonymously, which were used in our data analysis. Twenty-nine (46.8%) respondents fall within those with 5-10 years of clinical experience out of which none has completed the specialist training programme. Practitioners with above 10 years clinical experiences were 33 (53.2%) out of which 15 (45.5%) are specialists representing 24.2% of the total number of respondents. All the 15 respondents are actively involved in research activities and only five (33.3%) can utilize a software for statistical analysis unaided. Conclusion: This study has identified poor utilization of computer software for statistic analysis among dental researchers in eastern Nigeria. This is strongly associated with lack of exposure on the use of these software early enough especially during the undergraduate training. This paper therefore, calls for introduction of computer training programme in dental curriculum to enable practitioners develop the attitude of using computer software for their research.