OBJECTIVES: To determine the prevalence of oral Kaposi's sarcoma (KS)in Ugandan patients and the possible gender predominance of K.S lesions occurance if any. The study also aimed at finding the relationship between KS and HIV/AIDS. METHODS: A retrospective study of all cases visiting the Department of Oral Surgery, the national refferal hospital, for the period of 2000 to 2004. The patients histology records where retrieved and those with Kaposi's sarcoma were selected and entered into a predesigned form. RESULTS: Records showed that almost 95%of patients where referred known ISS patients. A total of 17,500 record forms were retrieved and of these 48% had KS. About 54% were males and the rest females. The total number of children was very small as compared to adults. CONCLUSIONS: The study has shown an increase in the prevalence of Oral Kaposi's sarcoma in Uganda in the last five years highest in 2004. Most common site is the hard palate. This finding may be due to an increase in treatment seeking behaviour and the awareness of the population about HIV/AIDS. This may also be due to an increase in the spread of the disease which in a way may be related to the antiretroviral therapy, whish covers up symptoms. The occurance shows no gender predominace, but is more in the middle aged and the youth. Treatment is mainly by chemotherapy.