Comparative Study of Biocompatability of 3 Different Gutta-Percha in Rats

Objective: This experimental study was designed to compare the in vivo effects of Ariadent gutta-percha with Roeko and Diadent. Methods: Altogether 29 mature Albinus rats were selected. Four intradermal incisions were made at the dorsal part of each rat, in three incised area a piece of each gutta-percha was placed and one of four incised area was assumed as negative control. Animals were sacrificed at 15, 30 and 60 day intervals and then subcutaneous connective tissues of rats were assessed histologically. Histological assessment was based on the amount of inflammatory cells. Results: Ariadent gutta-percha in 15 days interval is more reactive than Roeko and Diadent, but in 30 and 60 days intervals, tissue biocompatibility of Ariadent is the same as Roeko and Diadent and the difference was not significant. Conclusion: Iranian Ariadent gutta-percha can be considered as a substitute for another foreign gutta-perchas.