Fluoride Uptake and Remineralization From a Novel Fluoride Treatment

Objectives: The efficacy of a new fluoride treatment with 9,500ppm fluoride and a 15-minute treatment time was investigated in an in-vitro fluoride uptake and remineralization experiment in caries-like lesions against a negative control and two positive controls with different fluoride amounts (22,600ppm and 7,700ppm) and longer treatment times (4hr and 1hr).
Methods: Bovine enamel specimens were potted, polished, and demineralized to produce an artificial lesion. Vickers Surface Microhardness (VSMH) was measured, and lesions were stratified and allocated to four treatment groups (n=10): A-Artificial Saliva, B-3M™ Clinpro™ Clear Fluoride Treatment, C-Colgate^® Duraphat^® Varnish, and D-Ivoclar Vivadent Fluor Protector S. Enamel fluoride uptake (EFU) via biopsy method and VSMH measurements were taken after treatment (following instructions for use) and after a four-hour acid challenge. Net hardness gain was calculated (%VHN-Net). EFU, VSMH, and %VHN-Net values were compared using one-way ANOVA with Tukey’s test (p<0.05).
Results: See Table 1, where treatments not sharing a superscript letter are statistically different. Treatments B, C, and D had statistically equivalent EFU and statistically greater EFU than treatment A. Treatment B had statistically greater %VHN increase after treatment than treatments C and D, which had statistically equivalent %VHN increase after treatment. Treatments B, C, and D had statistically greater %VHN increase after treatment than treatment A. Finally, treatment B had statistically greater %VHN-Net than treatments A, C, and D.
Conclusions: The new fluoride treatment with a much shorter treatment time than conventional fluoride varnishes had statistically equivalent EFU compared to the positive controls, statistically greater EFU compared to the negative control, statistically greater %VHN increase after treatment compared to the positive and negative controls, and statistically greater %VHN-Net compared to the positive and negative controls. 3M and the 3M logo are trademarks of 3M. Other trademarks are the property of their respective owners. ©Solventum 2024.