IADR Abstract Archives
The Influence of FCP-COMPLEX for Inhibition on Tooth Demineralization
Objectives: This study aimed to evaluate the inhibition of demineralization in sound teeth using a fluoride-calcium-phosphate (FCP) COMPLEX solution with a fixed calcium concentration in patients at high risk of caries.
Methods: Forty bovine enamel and dentin samples were prepared. A 2 x 2 mm2 experimental area was made in the center of the labial surface of each sample. The samples were randomly assigned to four treatment groups: Control (deionized water), FCP0 (Fluoride: Calcium: Phosphate = 6:0:1), FCP1 (6:10:1), and FCP2 (6:20:1). Each treatment solution was applied for 10 minutes, followed by a 2-week pH cycling regimen (6 cycles/day). Mineral changes were qualitatively evaluated at each time point using Swept Source Optical Coherence Tomography (SS-OCT) and quantitatively assessed by micro-CT. Mineral densities were calculated into mineral loss and lesion depth. The tooth structure was evaluated using scanning electron microscopy. Statistical analysis for each data were performed.
Results: In the enamel group, FCP2 showed significantly less mineral loss compared to both the Control and FCP0 groups (p=0.04 and p=0.02, respectively). In the dentin group, FCP2 exhibited significantly less mineral loss compared to the Control group (p=0.003). The overall trend in mineral loss was FCP2 < FCP1 < FCP0 < Control. FCP2 also produced the shallowest lesion depths in both enamel and dentin, with significant differences compared to the Control group (p=0.01 for enamel and p=0.047 for dentin). Structural changes were detected by SEM.
Conclusions: The FCP-COMPLEX solution was found to enhance the inhibition of demineralization, likely due to its higher calcium concentration. Dentin demonstrated a stronger response than enamel, and the inhibitory effect of the FCP-COMPLEX was more pronounced in dentin.
Methods: Forty bovine enamel and dentin samples were prepared. A 2 x 2 mm2 experimental area was made in the center of the labial surface of each sample. The samples were randomly assigned to four treatment groups: Control (deionized water), FCP0 (Fluoride: Calcium: Phosphate = 6:0:1), FCP1 (6:10:1), and FCP2 (6:20:1). Each treatment solution was applied for 10 minutes, followed by a 2-week pH cycling regimen (6 cycles/day). Mineral changes were qualitatively evaluated at each time point using Swept Source Optical Coherence Tomography (SS-OCT) and quantitatively assessed by micro-CT. Mineral densities were calculated into mineral loss and lesion depth. The tooth structure was evaluated using scanning electron microscopy. Statistical analysis for each data were performed.
Results: In the enamel group, FCP2 showed significantly less mineral loss compared to both the Control and FCP0 groups (p=0.04 and p=0.02, respectively). In the dentin group, FCP2 exhibited significantly less mineral loss compared to the Control group (p=0.003). The overall trend in mineral loss was FCP2 < FCP1 < FCP0 < Control. FCP2 also produced the shallowest lesion depths in both enamel and dentin, with significant differences compared to the Control group (p=0.01 for enamel and p=0.047 for dentin). Structural changes were detected by SEM.
Conclusions: The FCP-COMPLEX solution was found to enhance the inhibition of demineralization, likely due to its higher calcium concentration. Dentin demonstrated a stronger response than enamel, and the inhibitory effect of the FCP-COMPLEX was more pronounced in dentin.
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