IADR Abstract Archives
Silver Core-Shell Particle in the Development of Antibacterial Dental Adhesives.
Objectives: This study aimed to formulate silver core-shell particles (Ag@SiO2) and incorporate them into an experimental adhesive resin to develop antibacterial dental adhesives.
Methods: Particles were synthesized via Stöber sol-gel route via the hydrolysis and controlled condensation of a silica shell with reduced silver in the core. Particles were evaluated by their physicochemical properties to understand the chemical composition, crystal structure, and morphology, in comparison to silver-free particles. The Ag@SiO2 particles were incorporated into a BisGMA/HEMA adhesive blend at 1wt%, 2.5wt%, and 5wt% concentrations. Controls without particle addition were used. Adhesives were characterized by their degree of conversion, softening in solvent, cytotoxicity, and antibacterial analysis.
Results: Spherical Ag@SiO2 particles were obtained with an average size of 683.51nm ± 93.58. The presence of silver was observed on the crystalline structure of Ag@SiO2. The degree of conversion was reduced when 5wt% Ag@SiO2 was used when compared to the control group and 1wt% Ag@SiO2 (p < 0.05). The higher concentration of Ag@SiO2 resulted in a statistically significant reduction in cell viability, with all groups reaching >90% cell viability. Antibacterial effect against S.mutans was observed for Ag@SiO2.
Conclusions: The control in silver core-shell particles was successfully obtained and promoted the formulation of adhesives with a suitable degree of conversion and able to control S.mutans in vitro, without generating a cytotoxic effect.
Methods: Particles were synthesized via Stöber sol-gel route via the hydrolysis and controlled condensation of a silica shell with reduced silver in the core. Particles were evaluated by their physicochemical properties to understand the chemical composition, crystal structure, and morphology, in comparison to silver-free particles. The Ag@SiO2 particles were incorporated into a BisGMA/HEMA adhesive blend at 1wt%, 2.5wt%, and 5wt% concentrations. Controls without particle addition were used. Adhesives were characterized by their degree of conversion, softening in solvent, cytotoxicity, and antibacterial analysis.
Results: Spherical Ag@SiO2 particles were obtained with an average size of 683.51nm ± 93.58. The presence of silver was observed on the crystalline structure of Ag@SiO2. The degree of conversion was reduced when 5wt% Ag@SiO2 was used when compared to the control group and 1wt% Ag@SiO2 (p < 0.05). The higher concentration of Ag@SiO2 resulted in a statistically significant reduction in cell viability, with all groups reaching >90% cell viability. Antibacterial effect against S.mutans was observed for Ag@SiO2.
Conclusions: The control in silver core-shell particles was successfully obtained and promoted the formulation of adhesives with a suitable degree of conversion and able to control S.mutans in vitro, without generating a cytotoxic effect.