IADR Abstract Archives
Enamel Remineralization Efficacy of SnF2 in an in Situ Remin Model.
Objectives: Dental caries remains the most prevalent chronic disease in both children and adults. Fluoride dentifrices are the most commonly used therapy for caries prevention.
Objective: The purpose of this study was to evaluate the enamel remineralization efficacy of the SnF2/silica dentifrice in an in-situ caries model.
Methods: This was a randomized, four-treatment, 4-period crossover study with a no fluoride control and 3 dentifrices with various levels of monofluorophosphate (250 ppm F, 1100 ppm F, 2800ppm) to test model sensitivity. All subjects were also asked to voluntarily participate in a fifth period, not included as part of the crossover design, where they used experimental SnF2/silica dentifrice in order to compare to the no fluoride control. 13 subjects completed the crossover portion and 12 completed the period 5. Shallow artificial caries lesions were prepared in enamel discs and surface microhardness was measured. The discs were mounted in modified partial dentures with gauze coverings to encourage plaque formation. Volunteers brushed daily with the dentifrices and wore their dentures throughout a 3 week period. Specimens were removed at days 7, 14 and 21 and remeasured for surface microhardness and assayed for fluoride uptake using a microdrill biopsy method. Remineralization was calculated using surface microhardness recovery. The experimental SnF2/silica dentifrice was compared to the no fluoride leg using a paired t-test.
Results: A quantitative dose response of monofluorophosphate levels was achieved with respect to fluoride uptake and enamel remineralization. Fluoride Uptake: SnF2 had statistically higher fluoride uptake than no fluoride treatment on Days 7, 14 and 21 (p<0.001). Surface Microhardness Recovery: The SnF2 treatment resulted in a statistically significantly higher SMH recovery compared to the no fluoride treatment on Days 7, 14 and 21 (p≤0.021).
Conclusions: The experimental SnF2/silica formulation was effective at enamel remineralization and fluoride uptake compared to no fluoride (p≤0.021).
Objective: The purpose of this study was to evaluate the enamel remineralization efficacy of the SnF2/silica dentifrice in an in-situ caries model.
Methods: This was a randomized, four-treatment, 4-period crossover study with a no fluoride control and 3 dentifrices with various levels of monofluorophosphate (250 ppm F, 1100 ppm F, 2800ppm) to test model sensitivity. All subjects were also asked to voluntarily participate in a fifth period, not included as part of the crossover design, where they used experimental SnF2/silica dentifrice in order to compare to the no fluoride control. 13 subjects completed the crossover portion and 12 completed the period 5. Shallow artificial caries lesions were prepared in enamel discs and surface microhardness was measured. The discs were mounted in modified partial dentures with gauze coverings to encourage plaque formation. Volunteers brushed daily with the dentifrices and wore their dentures throughout a 3 week period. Specimens were removed at days 7, 14 and 21 and remeasured for surface microhardness and assayed for fluoride uptake using a microdrill biopsy method. Remineralization was calculated using surface microhardness recovery. The experimental SnF2/silica dentifrice was compared to the no fluoride leg using a paired t-test.
Results: A quantitative dose response of monofluorophosphate levels was achieved with respect to fluoride uptake and enamel remineralization. Fluoride Uptake: SnF2 had statistically higher fluoride uptake than no fluoride treatment on Days 7, 14 and 21 (p<0.001). Surface Microhardness Recovery: The SnF2 treatment resulted in a statistically significantly higher SMH recovery compared to the no fluoride treatment on Days 7, 14 and 21 (p≤0.021).
Conclusions: The experimental SnF2/silica formulation was effective at enamel remineralization and fluoride uptake compared to no fluoride (p≤0.021).