IADR Abstract Archives
Stannous Fluoride vs Regular Fluoride Dentifrice in Plaque and Gingivitis Reduction
Objectives: The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the Stannous Fluoride dentifrice stabilized with K+ and polyphosphates (SNAP) compared to Regular Fluoride dentifrice after 3 and 6 months of product use.
Methods: Following consent and examinations of initial gingivitis and plaque scores, qualified subjects were instructed to brush twice daily with the toothbrush and dentifrice provided. The subjects were asked to return to the clinical site after 3 and 6 months of product use for examinations.
Results: The SNAP dentifrice provided statistically significant better plaque reductions than Regular Fluoride dentifrice at 3 and 6 months (15.5% and 21.2%, respectively). The SNAP dentifrice provided statistically significant better gingivitis reductions than Regular Fluoride dentifrice at 3 and 6 months (15.9% and 33.8%, respectively). The SNAP dentifrice provided statistically significant better plaque severity reductions than Regular Fluoride dentifrice at 3 and 6 months (22.6% and 37.3%, respectively). The SNAP dentifrice provided statistically significant better gingival severity (bleeding) reductions than Regular Fluoride dentifrice at 3 and 6 months (57.6% and 90.0%, respectively). The SNAP dentifrice provided statistically significant better plaque interproximal reductions than Regular Fluoride dentifrice at 3 and 6 months (15.4% and 22.3%, respectively). The SNAP dentifrice provided statistically significant better gingival interproximal reductions than Regular Fluoride dentifrice at 3 and 6 months (17.0% and 35.3%, respectively).
Conclusions: The results of this single-center, double-blind, parallel-group and randomized clinical study support the conclusion that, a fluoride dentifrice (SNAP) containing 0.454% stannous fluoride provided significantly greater reductions in dental plaque and gingivitis endpoints as compared to a commercially available fluoride dentifrice containing 0.76% sodium monofluorophosphate after 6 months of product use.
Methods: Following consent and examinations of initial gingivitis and plaque scores, qualified subjects were instructed to brush twice daily with the toothbrush and dentifrice provided. The subjects were asked to return to the clinical site after 3 and 6 months of product use for examinations.
Results: The SNAP dentifrice provided statistically significant better plaque reductions than Regular Fluoride dentifrice at 3 and 6 months (15.5% and 21.2%, respectively). The SNAP dentifrice provided statistically significant better gingivitis reductions than Regular Fluoride dentifrice at 3 and 6 months (15.9% and 33.8%, respectively). The SNAP dentifrice provided statistically significant better plaque severity reductions than Regular Fluoride dentifrice at 3 and 6 months (22.6% and 37.3%, respectively). The SNAP dentifrice provided statistically significant better gingival severity (bleeding) reductions than Regular Fluoride dentifrice at 3 and 6 months (57.6% and 90.0%, respectively). The SNAP dentifrice provided statistically significant better plaque interproximal reductions than Regular Fluoride dentifrice at 3 and 6 months (15.4% and 22.3%, respectively). The SNAP dentifrice provided statistically significant better gingival interproximal reductions than Regular Fluoride dentifrice at 3 and 6 months (17.0% and 35.3%, respectively).
Conclusions: The results of this single-center, double-blind, parallel-group and randomized clinical study support the conclusion that, a fluoride dentifrice (SNAP) containing 0.454% stannous fluoride provided significantly greater reductions in dental plaque and gingivitis endpoints as compared to a commercially available fluoride dentifrice containing 0.76% sodium monofluorophosphate after 6 months of product use.