IADR Abstract Archives
Efficacy of a Stannous Fluoride Toothpaste Stabilized With K+ and Polyphosphates (SNAP) on Immediate Tooth Sensitivity Relief
Objectives: To compare the clinical efficacy among SNAP, a potassium (K)-based, and a non-desensitizing regular 0.76% sodium monofluorophosphate (Na2PFO3) dentifrices on dentin hypersensitivity reduction after brushing for 7 days.
Methods: A phase III, randomized, double-blind, single-center, and three-cell parallel-group clinical study was conducted on healthy male and female subjects (18-70 years) from the Costa Mesa, California area. Subjects with at least two hypersensitive teeth with dentin exposure due to cervical erosion/abrasion or gingival recession were included. Dentin hypersensitivity was assessed via tactile and air blast stimuli. Study subjects were randomized into 3 groups: 1. Test: SNAP 2. Positive Control: A commercially available potassium-based dentifrice, and 3. Negative Control: a non-desensitizing regular fluoride dentifrice containing 0.76% Na2PFO3. Dentin hypersensitivity assessments (tactile and air blast hypersensitivity) and oral hard and soft tissue examinations were conducted at the baseline visit. Study subjects brushed twice daily for 2 minutes with their assigned dentifrice for 7 days. Mean tactile and air blast hypersensitivity scores were calculated for each treatment group. Tooth hypersensitivity assessments and oral examinations were repeated after 7-days.
Results: One-hundred-twenty (120) subjects complied with the protocol and completed the clinical study. After 7-days of product use, subjects in the SNAP group (relative to subjects in the K-based dentifrice group) exhibited statistically significant improvement in (79.8%; p<0.001) in tactile hypersensitivity and (41.1%; p<0.001) in air blast hypersensitivity. Relative to subjects in the regular fluoride group, those in the SNAP group exhibited statistically significant improvement (90.2%; p<0.001) in tactile hypersensitivity and (47.9%; p<0.001) in air blast hypersensitivity.
Conclusions: The fluoride dentifrice containing SNAP provided a statistically significant dentin hypersensitivity improvement after 7 days of use as compared to a commercially available potassium-based dentifrice and a non-desensitizing regular fluoride dentifrice containing 0.76% sodium monofluorophosphate.
Methods: A phase III, randomized, double-blind, single-center, and three-cell parallel-group clinical study was conducted on healthy male and female subjects (18-70 years) from the Costa Mesa, California area. Subjects with at least two hypersensitive teeth with dentin exposure due to cervical erosion/abrasion or gingival recession were included. Dentin hypersensitivity was assessed via tactile and air blast stimuli. Study subjects were randomized into 3 groups: 1. Test: SNAP 2. Positive Control: A commercially available potassium-based dentifrice, and 3. Negative Control: a non-desensitizing regular fluoride dentifrice containing 0.76% Na2PFO3. Dentin hypersensitivity assessments (tactile and air blast hypersensitivity) and oral hard and soft tissue examinations were conducted at the baseline visit. Study subjects brushed twice daily for 2 minutes with their assigned dentifrice for 7 days. Mean tactile and air blast hypersensitivity scores were calculated for each treatment group. Tooth hypersensitivity assessments and oral examinations were repeated after 7-days.
Results: One-hundred-twenty (120) subjects complied with the protocol and completed the clinical study. After 7-days of product use, subjects in the SNAP group (relative to subjects in the K-based dentifrice group) exhibited statistically significant improvement in (79.8%; p<0.001) in tactile hypersensitivity and (41.1%; p<0.001) in air blast hypersensitivity. Relative to subjects in the regular fluoride group, those in the SNAP group exhibited statistically significant improvement (90.2%; p<0.001) in tactile hypersensitivity and (47.9%; p<0.001) in air blast hypersensitivity.
Conclusions: The fluoride dentifrice containing SNAP provided a statistically significant dentin hypersensitivity improvement after 7 days of use as compared to a commercially available potassium-based dentifrice and a non-desensitizing regular fluoride dentifrice containing 0.76% sodium monofluorophosphate.