Association of Specific Genes Polymorphisms With Temporomandibular Disorders
Objectives: Temporomandibular disorders (TMD) represent heterogeneous musculoskeletal conditions. Their complex etiology is yet to be thoroughly explored. The aim of the research presented is to investigate genetic predisposition as a risk factor for the TMD onset.
Methods: Anamnestic and clinical data have been collected. Genomic DNA will be extracted from the buccal swabs obtained from TMD patients (DC/TMD) and control subjects, and used for the determination of selected polymorphisms by TaqMan SNP Genotyping Assays (Carlsbad, United States, Life Technologies). Gene polymorphisms clustering is expected to be related to the presence or absence of TMD. Whether specific clusters can be related to the source of pain and its intensity, presence of bone changes, psychological features, previous orthodontic therapy and treatment response to occlusal splint therapy will be explored.
Results: We expect to show that a particular genotype may be a potential risk factor for the development of TMD.
Conclusions: This innovative approach, focused on genetic predisposition for TMD has the potential for development of a commercial genetic test which would allow for risk estimation with respect to the TMD onset. Accordingly, it may be a potential tool to be used for decision making on early interventions and active avoidance of environmental risk factors.