IADR Abstract Archives

Association of Specific Genes Polymorphisms With Temporomandibular Disorders

Objectives: Temporomandibular disorders (TMD) represent heterogeneous musculoskeletal conditions. Their complex etiology is yet to be thoroughly explored. The aim of the research presented is to investigate genetic predisposition as a risk factor for the TMD onset.
Methods: Anamnestic and clinical data have been collected. Genomic DNA will be extracted from the buccal swabs obtained from TMD patients (DC/TMD) and control subjects, and used for the determination of selected polymorphisms by TaqMan SNP Genotyping Assays (Carlsbad, United States, Life Technologies). Gene polymorphisms clustering is expected to be related to the presence or absence of TMD. Whether specific clusters can be related to the source of pain and its intensity, presence of bone changes, psychological features, previous orthodontic therapy and treatment response to occlusal splint therapy will be explored.
Results: We expect to show that a particular genotype may be a potential risk factor for the development of TMD.
Conclusions: This innovative approach, focused on genetic predisposition for TMD has the potential for development of a commercial genetic test which would allow for risk estimation with respect to the TMD onset. Accordingly, it may be a potential tool to be used for decision making on early interventions and active avoidance of environmental risk factors.

2022 AADOCR/CADR Annual Meeting
Hybrid, Atlanta, Georgia
Oral Medicine & Pathology Research
  • Zlendić, Marko  ( School of Dental Medicine , Zagreb , Croatia )
  • Vrbanović, Ema  ( School of Denta Medicine, University of Zagreb , Zagreb , Grad Zagreb , Croatia )
  • Gall Trošelj, Koraljka  ( Rudjer Boskovic Institute , Zagreb , Croatia )
  • Tomljanović, Marko  ( Rudjer Boskovic Institute , Zagreb , Croatia )
  • Alajbeg, Iva  ( School of Dental Medicine , Zagreb , Croatia )
  • NONE
    Croatian Science Foundation Project IP-2019-04-6211 (PI: Iva Alajbeg) and “Young Researchers’ Career Development Project - Training of Doctoral Students” (DOK-2020-01) (student: Marko Zlendić)
    IN PERSON Interactive Talk Session
    Molecular Mechanisms of Tempomandibular Disorders
    Saturday, 03/26/2022 , 11:00AM - 12:30PM