IADR Abstract Archives
Systemic Steroids are Associated With Increased Implant Failure
Objectives: To assess whether use of systemic steroids affects the outcome of dental implant survival among women.
Methods: Following IRB approval, medical and dental records of subjects (N=1,480) presenting to the Postgraduate Periodontics Clinic at the University at Buffalo School of Dental Medicine during 2000-2017 were initially considered. Study exclusions were age less than 21 years, pregnancy, or male gender. Presence of systemic factors such as smoking history, presence of diabetes, autoimmune diseases, and use of potentially immunomodulating medication, were assessed. Implant failure rates from female patients using systemic steroids (including prednisone, hormonal replacement therapy, or oral contraceptives) were compared with failure rates from patients not taking those medications. Implant failure was defined as implant loss within the study period. Statistical analysis was performed using 2 x 2 contingency testing via Chi-square tests of independence with significance set at P<.05, using IBM SPSS Statistics v26.
Results: The implant failure rate among 65 patients taking steroid medications was 7.69%, vs. 1.54% failure among 712 patients not taking steroids (P<.001). That relationship persisted after adjusting for smoking and the presence of diabetes, with 8.47% implant failure among 59 patients taking steroids, vs. 1.54% failure among 585 patients not taking steroids (P<.001). No statistically significant differences in patient plaque control, using either the Ramfjord index sampling technique or via whole-mouth plaque detection, were found between the experimental and control two groups, suggesting that any differences in patient home care were not confounding factors in this study.
Conclusions: Among women, use of systemic steroids is associated with a 5-fold increase in the rate of dental implant failure, independent of the presence of smoking or diabetes.
Methods: Following IRB approval, medical and dental records of subjects (N=1,480) presenting to the Postgraduate Periodontics Clinic at the University at Buffalo School of Dental Medicine during 2000-2017 were initially considered. Study exclusions were age less than 21 years, pregnancy, or male gender. Presence of systemic factors such as smoking history, presence of diabetes, autoimmune diseases, and use of potentially immunomodulating medication, were assessed. Implant failure rates from female patients using systemic steroids (including prednisone, hormonal replacement therapy, or oral contraceptives) were compared with failure rates from patients not taking those medications. Implant failure was defined as implant loss within the study period. Statistical analysis was performed using 2 x 2 contingency testing via Chi-square tests of independence with significance set at P<.05, using IBM SPSS Statistics v26.
Results: The implant failure rate among 65 patients taking steroid medications was 7.69%, vs. 1.54% failure among 712 patients not taking steroids (P<.001). That relationship persisted after adjusting for smoking and the presence of diabetes, with 8.47% implant failure among 59 patients taking steroids, vs. 1.54% failure among 585 patients not taking steroids (P<.001). No statistically significant differences in patient plaque control, using either the Ramfjord index sampling technique or via whole-mouth plaque detection, were found between the experimental and control two groups, suggesting that any differences in patient home care were not confounding factors in this study.
Conclusions: Among women, use of systemic steroids is associated with a 5-fold increase in the rate of dental implant failure, independent of the presence of smoking or diabetes.