Objectives: To perform retrospective analyses of the effects of statin usage on chronic periodontitis. Methods: At two university centers, data were collected from the dental records of 280 subjects who were (1) aged 40 years or older, (2) had an initial diagnosis of generalized moderate/severe chronic periodontitis, and (3) did and did not take statins. Demographic and clinical data were obtained for age, gender, smoking status, diabetes, number of teeth, probing depths (PD), and bleeding on probing (BOP). The Periodontal Inflammatory Burden Index (PIBI) was used to estimate systemic effects of periodontitis. For nominal data, probabilities and 95% confidence intervals were calculated. For continuous data, distributions were tested for normality with the Shapiro Wilk-W test. Most distributions were non-normal; therefore, median values plus 25th and 75th percentiles was used for descriptive statistics. To determine how PIBI differed between groups the Fisher’s exact and Wilcoxon-Mann-Whitney tests were used. Results: PIBI was significantly (P<0.001) lower by 43% in subjects who took statins compared with those who did not. Our analysis also considered how PIBI differed between: (1) smokers and non-smokers, (2) diabetics and non-diabetics, and (3) centers. We additionally determined how the PIBI lowering effect of statins was altered by these variables. PIBI values were lower in the statin group for both smokers and non-smokers and in both diabetics and non-diabetics. Both centers presented lower PIBI values in the statin group compared with the non-statin group. Conclusions: Subjects taking statins exhibited fewer signs of periodontal inflammatory damage compared with non-takers. Our findings support the possibility that the use of oral statins may have a positive impact on periodontal disease severity. The apparent beneficial effects of statins could be attributed to their pleiotropic anti-inflammatory effects. However, prospective studies are needed to better establish and understand the effect of statins on periodontitis.