Single Nucleotide Polymorphisms Influences Treatment Response of Localized Aggressive Periodontitis

Objectives: Our previous study has shown the influence of inflammatory response on the clinical response to treatment in localized aggressive periodontitis (LAP). The goal of this study was to evaluate whether single nucleotide polymorphisms influences the clinical response to treatment in children with localized aggressive periodontitis (LAP).

Methods: Prior to treatment, peripheral blood was collected from 119 African-American participants aged 5-25 years, free of systemic diseases, diagnosed with LAP. Twenty-four SNPs in 13 different genes were evaluated. Periodontal clinical parameters were taken prior to and at 3, 6, 12, 18 and 24 months following treatment with mechanical debridement and systemic antibiotics. SNPs frequencies were correlated with periodontal clinical parameters before and after treatment.
Results: Genotype frequencies for TNFα (rs1900683, 1800629 and 2229094), IL6 (rs10499563), TLR2 (rs3804099 and 3804100), TLR4 (rs4986790 and 11536865), CXCL5 (rs425535), and P2RX7 (rs208294) were significantly associated with different clinical parameters of LAP treatment response (p< 0.05).
Conclusions: Different genotypes in several inflammatory genes were associated with a differentiated magnitude of clinical response to non-surgical treatment in LAP patients. Further studies are required in order to establish a predictive model of treatment response based on genotype frequencies of key genes.