IADR Abstract Archives

Evaluation of Sensory Attributes of an Experimental Mouthwash

Objectives: To investigate sensory attributes of an experimental mouthwash (MW) as measured by the Post-Product Use Sensory Questionnaire (PPUSQ) versus water.
Methods: A randomised, examiner blind, parallel group trial in participants with (n=28) or without (n=72) Sjogren’s syndrome (SS) experiencing dry mouth symptoms. Under supervision, participants swished with 15mL of MW for 30 seconds (n=53) or sipped 15mL of water (n=47). They completed the PPUSQ immediately after supervised use on Days 1, 3, and 8. Participants rated Q1) How much they liked the product (1–6 scale from ‘Did not like it at all’ to ‘Like it extremely); Q2) How pleasant the flavor was (1–5 scale from ‘Not pleasant at all’ to ‘Extremely pleasant’); Q3) How gentle the product was (1–7 scale from ‘Not gentle at all’ to ‘The most gentle product imaginable’); and Q4) How fresh their mouth felt after using the product (1–5 scale from ‘Not at all fresh’ to ‘Extremely fresh’).
Results: Difference is MW group score minus water group score; a positive difference favors the MW group (Table 1). Overall there were few between-group differences in terms of liking the product and rating the flavor pleasance. The MW was perceived as more fresh with water perceived as more gentle. Based on adverse events, study products were generally well-tolerated.
Conclusions: Mean PPUSQ scores immediately after use indicated similarities between water and an experimental MW for likability and pleasantness but differences for gentleness and freshness.
AADR/CADR Annual Meeting
2018 AADR/CADR Annual Meeting (Fort Lauderdale, Florida)
Fort Lauderdale, Florida
2018
0080
Pharmacology/Therapeutics/Toxicology
  • Singh, Mabi  ( School of Dental Medicine, Tufts University , Boston , Massachusetts , United States )
  • Jose, Anto  ( GlaxoSmithKline Consumer Healthcare , Weybridge , Surrey , United Kingdom )
  • Farag, Arwa  ( School of Dental Medicine , Boston , Massachusetts , United States )
  • Magnuson, Britta  ( Tufts University , Boston , Massachusetts , United States )
  • Kafasis, Nicolette  ( Tufts University School of Dental Medicine , Boston , Massachusetts , United States )
  • Tzavaras, Elizabeth  ( Tufts University , Boston , Massachusetts , United States )
  • Desai, Bhavik  ( Tufts University School of Dental Medicine , Boston , Massachusetts , United States )
  • Varghese, Roshan  ( GlaxoSmithKline , Weybridge , United Kingdom )
  • Papas, Athena  ( Tufts University , Boston , Massachusetts , United States )
  • This study was sponsored by GSK Consumer Healthcare.
    This study was sponsored by GSK Consumer Healthcare of whom A Jose and R Varghese are employees. ML Singh, A Farag, A Papas, B Magnuson and B Desai are employees of Tufts University, which has received funding from GSK Consumer Healthcare.
    Oral Session
    Pharmacology/Therapeutics/Toxicology I
    Wednesday, 03/21/2018 , 01:30PM - 03:00PM
    Table 1
     Day 1Day 3Day 8 
    Q1-0.21 (-0.67,0.25) 0.3590.11 (-0.36,0.58) 0.6350.03 (-0.42,0.48) 0.888 
    Q20.23 (-0.27,0.73) 0.3630.58 (0.11,1.05) 0.0170.16(-0.32,0.65) 0.501 
    Q3-0.56 (-1.06,-0.05) 0.031-0.54 (-1.00,-0.08) 0.021-0.57 (-1.03,-0.11) 0.016 
    Q40.73 (0.29,1.17) 0.0010.71 (0.26,1.16) 0.0020.89 (0.46,1.33) <.001 
    Adjusted mean difference in scores (95% confidence intervals) and p-value from analysis of variance.