Comparison of Blood Values in Sjogrens and Sicca Patients

Objectives: Diagnosis of Sjogrens is difficult. We have seen a correlation between FACIT and ESSDAI in our Sicca clinic population that is significant to the 0.0001 level in 129 patients. We had blood values available for 39 of these patients and explored to see if any of their blood values differed between confirmed Sjogrens and Sicca patients. We especially looked at inflammatory markers and immunoglobulins in particular.
Objective: to analyze relationship between different blood values and Functional Assessment of Chronic Illness Therapy (FACIT) Scores in Sjogrens and sicca.
Methods: Thirty-nine (2 males) patients with mean age of 61.3 +/- 11.7 for the Sicca and 56.2 +/- 12.8 and were included in the study. 18, Sicca and 21 were diagnosed Sjogren’s. Reported blood values for WBC, absolute basophils, eosinophils, monocytes, lymphocytes ,and neutrophil, rbc, hct, hb, platelets, creatinine, esr, C3, C4, CK, crp, cryoglobulin, IGG, IGM, IGA, ANA ,SSA, SSB and RF were measured. The mean of FACIT scores and ESSDAI scores were calculated
Results: The mean FACIT scores calculated were 27.24 (+/-) for Sicca and 38.64 (+/-) for Sjogrens. The mean ESSDAI scores were 5.28 +/- 4.96 for Sicca and 10.24 +/- 13.19 for Sjogren’s. Kruskal- Wallis Analysis showed that CRP, SSA, SSB, IGG, IGM were significantly different in Sjogren's vs Sicca patients. See table
Conclusions: Immunoglobulins, CRP ESSDAI and Fatigue Scores among SICCA, diagnosed Sjogren’s should be looked at in addition to SSA and lip biopsy when diagnosing and treating Sjogren's Syndrome. Larger studies need to be conducted to establish this relationship .