β-Tricalcium Phosphate Influence Bone Healing in Critical Surgical Defects

Objectives: The aim of the investigation was to histologically and histometrically analyze the effect of using β-Tricalcium Phosphate (RTR) on bone healing in surgically created critical-size defects created in rat tibia.
Methods: Critical bone defects were created in the left and right tibiae of 32 Wistar rats and were randomly divided into two groups: clot group (defect filled with blood clot) and RTR group (defects filled with RTR). After 30 and 90 days post-surgery (n=8), the rats were killed and the tibiae was removed and processed for evaluation in hematoxylin-eosin stain. Two parameters were analyzed: total bone healing area and cortical bone healing area. The statistical tests were performed (P<.05).
Results: RTR group demonstrated superior bone healing when compared to the clot group at 30 days and 90 days, in the two analyzed parameters (P<.05).
Conclusions: The RTR^® influence bone healing process on the critical surgical bone defects in rat’s tibiae.