Evaluation of Plasma Rich in Growth Factors in the Treatment of Grade II Furcation Defects

Objectives: The current research was conducted to compare the additive effect of combined guided tissue regeneration (GTR) and plasma-rich in growth factor (PRGF) in the treatment of grade II furcation defects on mandibular molars.
Methods: A randomized, triple-blinded, split-mouth study was designed. This pilot study included patients with a moderate to severe chronic periodontitis with bilateral grade II furcation involvement of first or second mandibular molars . Each side of mouth was randomly allocated for the treatment with either GTR and PRGF or PRGF by itself. Plaque index, gingival index, vertical clinical attachment level, vertical probing depth, recession depth (REC), horizontal probing depth, fornix to alveolar crest (FAC), fornix to base of defect (FBD), furcation vertical component and furcation horizontal component (FHC) were recorded. .
Results: Eight patients were finally enrolled for this study. Overly, general and specific clinical and furcation parameters were improved except REC that was deteriorated insignificantly and FAC improved not significantly. Intergroup comparison revealed better improvement of FHC in GTR/PRGF group (P = 0.02). Altman’s nomogram, Kolmogorov–Smirnov test, Friedman test, general linear model, repeated measures, and paired t-test were used as statistical analysis in this research.
Conclusions: A significant improvement in the Grade II furcation defects treated with either GTR or PRGF/GTR was noticed. Further large-scale trials are needed to reveal differences of mentioned treatment in more details.